Efficient synthesis of amino-pyridine derivatives by copper catalyzed amination reactions

M. K. Elmkaddem (1) , Cédric Fischmeister (1) , C. M. Thomas (1) , J.-L. Renaud (2)

1 ISCR - Institut des Sciences Chimiques de Rennes
2 LCMT - Laboratoire de chimie moléculaire et thioorganique

A copper(I) catalyzed amination reaction utilizing aqueous ammonia and operating under mild conditions is presented. This method was employed for the efficient synthesis of various aminopyridine derivatives bearing electron withdrawing and electron donating groups.

Domaines: Catalyse

M. K. Elmkaddem, Cédric Fischmeister, C. M. Thomas, J.-L. Renaud. Efficient synthesis of amino-pyridine derivatives by copper catalyzed amination reactions. Journal of the Chemical Society, Chemical Communications, 2010, 46, pp.925-927. ⟨10.1039/b916569j⟩. ⟨hal-00492596⟩