Synthesis of α-Alkynyl-β,β,β-trifluoroalanine Derivatives by Sonogashira Cross-Coupling Reaction
Résumé
An efficient route to new α-CF3-α-amino acid derivatives bearing an arylalkynyl moiety at the α-carbon atom has been developed. The method is based on palladium-catalyzed cross-coupling of the corresponding α-propargyl (ethynyl) α-amino esters with aryl halides to afford the amino acid derivatives with an internal triple bond that is suitable for further modifications.