Model of cap-dependent translation initiation in sea urchin: a step towards the eukaryotic translation regulation network.

Robert Bellé 1 Sylvain Prigent 2 Anne Siegel 3 Patrick Cormier 1
2 ARIANA - Inverse problems in earth monitoring
CRISAM - Inria Sophia Antipolis - Méditerranée , Laboratoire I3S - SIS - Signal, Images et Systèmes
3 SYMBIOSE - Biological systems and models, bioinformatics and sequences
IRISA - Institut de Recherche en Informatique et Systèmes Aléatoires, Inria Rennes – Bretagne Atlantique
Abstract : The large and rapid increase in the rate of protein synthesis following fertilization of the sea urchin egg has long been a paradigm of translational control, an important component of the regulation of gene expression in cells. This translational up-regulation is linked to physiological changes that occur upon fertilization and is necessary for entry into first cell division cycle. Accumulated knowledge on cap-dependent initiation of translation makes it suited and timely to start integrating the data into a system view of biological functions. Using a programming environment for system biology coupled with model validation (named Biocham), we have built an integrative model for cap-dependent initiation of translation. The model is described by abstract rules. It contains 51 reactions involved in 74 molecular complexes. The model proved to be coherent with existing knowledge by using queries based on computational tree logic (CTL) as well as Boolean simulations. The model could simulate the change in translation occurring at fertilization in the sea urchin model. It could also be coupled with an existing model designed for cell-cycle control. Therefore, the cap-dependent translation initiation model can be considered a first step towards the eukaryotic translation regulation network.
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Submitted on : Tuesday, May 25, 2010 - 4:35:41 PM
Last modification on : Thursday, December 13, 2018 - 1:28:26 AM

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Robert Bellé, Sylvain Prigent, Anne Siegel, Patrick Cormier. Model of cap-dependent translation initiation in sea urchin: a step towards the eukaryotic translation regulation network.. Molecular Reproduction and Development, Wiley, 2010, 77 (3), pp.257-64. ⟨10.1002/mrd.21142⟩. ⟨hal-00486418⟩

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