Effect of prior treatment with resveratrol on density and structure of rat long bones under tail-suspension

Abstract : Physical inactivity during space flight or prolonged bed rest causes rapid and marked loss of bone mass in humans. Resveratrol, a red wine polyphenol that is currently under study for its therapeutic antioxidant properties, has been shown to significantly modulate biomarkers of bone metabolism, i.e., to promote osteoblast differentiation and to prevent bone loss induced by estrogen deficiency. However, there is no direct evidence supporting its inhibitory effect toward bone loss during physical inactivity. In the present study, effects of resveratrol on bone mineral density (BMD), bone mineral content, and bone structure were examined in the femora and tibiae of tail-suspended and unsuspended rats using X-ray micro-computed tomography (micro-CT). Rats were treated with 400 mg/kg/day of resveratrol for 45 days and half of them were suspended during the last 2 weeks of treatment. Suspension caused a decrease in tibial and femoral BMD and deterioration of trabecular and cortical bone. Bone deterioration during suspension was paralleled by increased bone marrow area, which could be caused by an increase in stromal cells with osteoclastogenic potential or in adipocytes. Resveratrol had a preventive effect against bone loss induced by hindlimb immobilization. In particular, trabecular bone in the proximal tibial metaphysis was totally preserved in rats treated with resveratrol before tail-suspension.
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Journal articles
Journal of Bone and Mineral Metabolism, Springer Verlag (Germany), 2011, 29, pp.15-22. <10.1007/s00774-010-0187-y>


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Submitted on : Tuesday, May 25, 2010 - 3:50:31 PM
Last modification on : Friday, December 14, 2012 - 10:58:47 AM

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Caroline Habold, Iman Momken, Ali Ouadi, Virgile Bekaert, David Brasse. Effect of prior treatment with resveratrol on density and structure of rat long bones under tail-suspension. Journal of Bone and Mineral Metabolism, Springer Verlag (Germany), 2011, 29, pp.15-22. <10.1007/s00774-010-0187-y>. <hal-00486366>

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