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Human papillomavirus (HPV) genotype distribution in invasive cervical cancers in France: EDITH study.

Abstract : Invasive cervical cancer (ICC) remains a significant cause of morbidity and mortality in France. Since human papillomavirus (HPV) is the necessary cause of ICC, the aim of this study was to assess the type-specific prevalence of HPV in ICC in France in order to locally evaluate the potential benefit of an HPV 16/18 L1 virus-like particles (VLP) vaccination. A total of 516 histological specimens collected in 15 centers were analyzed. Among them, 86% had a diagnosis of squamous cell carcinoma (SCC) whereas 14% were adenocarcinomas (ADC). HPV genotyping was performed using the INNO-LiPA assay allowing the specific detection of 24 HPV genotypes both high risk (HR) and low risk (LR). The overall HPV prevalence in ICC was 97%. The most prevalent genotypes were HPV 16 (73%) and HPV 18 (19%) followed by HPV 31 (7%), 33, 68, 45, 52 and 58 (4.1-2.3%). HPV 16 and/or 18 were associated with 82% of ICC, 10% being HPV 16 and 18 coinfections. While HPV 16 was the most prevalent type in both SCC (74%) and ADC (64%), HPV 18 was by far more prevalent in ADC (37%) compared to SCC (16%; p < 0.001). Multiple infections with at least two different HR HPV genotypes were observed in 22% of ICC. Given the high HPV 16/18 prevalence and taking into account possible production of crossneutralizing antibodies against other HPV types, HPV 16/18 L1 VLP vaccination would be expected to significantly reduce the burden of ICC in France.
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Contributor : Pascale Viala <>
Submitted on : Wednesday, May 19, 2010 - 4:08:02 PM
Last modification on : Wednesday, September 16, 2020 - 2:20:04 PM

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Jean-Luc Prétet, Anne-Carole Jacquard, Xavier Carcopino, Jean-François Charlot, Damien Bouhour, et al.. Human papillomavirus (HPV) genotype distribution in invasive cervical cancers in France: EDITH study.. International Journal of Cancer, Wiley, 2008, 122 (2), pp.428-32. ⟨10.1002/ijc.23092⟩. ⟨hal-00484957⟩



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