R. Jahn and R. H. Scheller, SNAREs ??? engines for membrane fusion, Nature Reviews Molecular Cell Biology, vol.12, issue.9, 2006.
DOI : 10.1038/362318a0

T. Sollner, S. W. Whiteheart, M. Brunner, H. Erdjument-bromage, S. Geromanos et al., SNAP receptors implicated in vesicle targeting and fusion, Nature, vol.362, issue.6418, pp.318-324, 1993.
DOI : 10.1038/362318a0

T. Weber, B. V. Zemelman, J. A. Mcnew, B. Westermann, M. Gmachl et al., SNAREpins: Minimal Machinery for Membrane Fusion, Cell, vol.92, issue.6, pp.759-772, 1998.
DOI : 10.1016/S0092-8674(00)81404-X

B. L. Grosshans, D. Ortiz, and P. Novick, Rabs and their effectors: Achieving specificity in membrane traffic, Proceedings of the National Academy of Sciences, vol.103, issue.32, 2006.
DOI : 10.1073/pnas.0601617103

T. Tsuboi and M. Fukuda, Rab3A and Rab27A cooperatively regulate the docking step of dense-core vesicle exocytosis in PC12 cells, Journal of Cell Science, vol.119, issue.11, pp.2196-2203, 2006.
DOI : 10.1242/jcs.02962

T. Tsuboi and M. Fukuda, The C2B Domain of Rabphilin Directly Interacts with SNAP-25 and Regulates the Docking Step of Dense Core Vesicle Exocytosis in PC12 Cells, Journal of Biological Chemistry, vol.280, issue.47, pp.39253-39259, 2005.
DOI : 10.1074/jbc.M507173200

H. Gomi, S. Mizutani, K. Kasai, S. Itohara, and T. Izumi, Granuphilin molecularly docks insulin granules to the fusion machinery, The Journal of Cell Biology, vol.18, issue.1, pp.99-109, 2005.
DOI : 10.1074/jbc.M005479200

S. Brenner, The genetics of caenorhabdits elegans, Genetics, vol.77, pp.71-94, 1974.

P. Novick and R. Schekman, Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae, Proceedings of the National Academy of Sciences, vol.76, issue.4, 1979.
DOI : 10.1073/pnas.76.4.1858

M. Verhage, A. S. Maia, J. J. Plomp, A. B. Brussaard, J. H. Heeroma et al., Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion, Science, vol.287, issue.5454, pp.864-869, 2000.
DOI : 10.1126/science.287.5454.864

S. D. Harrison, K. Broadie, J. Van-de-goor, and G. M. Rubin, Mutations in the drosophila Rop gene suggest a function in general secretion and synaptic transmission, Neuron, vol.13, issue.3, pp.555-566, 1994.
DOI : 10.1016/0896-6273(94)90025-6

. Licenced-copy, Copying is not permitted, except with prior permission and as allowed by law, p.13

Y. Hata, C. A. Slaughter, and T. C. Sudhof, Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin, Nature, vol.366, issue.6453, pp.347-351, 1993.
DOI : 10.1038/366347a0

J. Pevsner, S. C. Hsu, and R. Scheller, n-Sec1: a neural-specific syntaxin-binding protein., Proc.Natl.Acad.Sci.USA. 91, pp.1445-1449, 1994.
DOI : 10.1073/pnas.91.4.1445

C. Dascher, R. Ossig, D. Gallwitz, H. D. Schmitt, R. F. Verhage et al., Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the ras superfamily The role of Rab3a in secretory vesicle docking requires association/dissociation of guanidine phosphates and Munc18-1, 16 van Weering, pp.872-885, 1991.

R. B. Sutton, D. Fasshauer, R. Jahn, and A. T. Brunger, Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4A resolution, Nature, vol.395, pp.347-353, 1998.

O. M. Schluter, F. Schmitz, R. Jahn, C. Rosenmund, and T. C. Sudhof, A Complete Genetic Analysis of Neuronal Rab3 Function, Journal of Neuroscience, vol.24, issue.29, pp.6629-6637, 2004.
DOI : 10.1523/JNEUROSCI.1610-04.2004

T. R. Mahoney, Q. Liu, T. Itoh, S. Luo, G. Hadwiger et al., Regulation of Synaptic Transmission by RAB-3 and RAB-27 in Caenorhabditis elegans, Molecular Biology of the Cell, vol.17, issue.6, pp.2617-2625, 2006.
DOI : 10.1091/mbc.E05-12-1170

T. Voets, R. Toonen, E. C. Brian, H. De-wit, T. Moser et al., Munc18-1 Promotes Large Dense-Core Vesicle Docking, Neuron, vol.31, issue.4, pp.581-591, 2001.
DOI : 10.1016/S0896-6273(01)00391-9

URL : http://doi.org/10.1016/s0896-6273(01)00391-9

R. J. Fisher, J. Pevsner, and R. D. Burgoyne, Control of Fusion Pore Dynamics During Exocytosis by Munc18, Science, vol.291, issue.5505, pp.875-878, 2001.
DOI : 10.1126/science.291.5505.875

B. L. Scott, J. S. Van-komen, H. Irshad, S. Liu, K. A. Wilson et al., Sec1p directly stimulates SNARE-mediated membrane fusion in vitro, The Journal of Cell Biology, vol.15, issue.1, pp.75-85, 2004.
DOI : 10.1074/jbc.270.43.25328

J. Shen, D. C. Tareste, F. Paumet, J. E. Rothman, and T. J. Melia, Selective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins, Cell, vol.128, issue.1, pp.183-195, 2007.
DOI : 10.1016/j.cell.2006.12.016

R. D. Burgoyne and A. Morgan, Membrane Trafficking: Three Steps to Fusion, Current Biology, vol.17, issue.7, pp.255-258, 2007.
DOI : 10.1016/j.cub.2007.02.006

B. Yang, M. Steegmaier, L. C. Gonzalez, and R. H. Scheller, Nsec1 Binds a Closed Conformation of Syntaxin1a, The Journal of Cell Biology, vol.11, issue.2, pp.247-252, 2000.
DOI : 10.1074/jbc.274.9.5649

K. M. Misura, R. H. Scheller, and W. I. Weis, Three-dimensional structure of the neuronal-Sec1???syntaxin 1a complex, Nature, vol.404, issue.6776, pp.355-362, 2000.
DOI : 10.1038/35006120

I. Dulubova, S. Sugita, S. Hill, M. Hosaka, I. Fernandez et al., A conformational switch in syntaxin during exocytosis: role of munc18, The EMBO Journal, vol.18, issue.16, pp.4372-4382, 1999.
DOI : 10.1093/emboj/18.16.4372

I. Dulubova, T. Yamaguchi, Y. Gao, S. Min, I. Huryeva et al., How Tlg2p/syntaxin 16 'snares' Vps45, The EMBO Journal, vol.21, issue.14, pp.3620-3631, 2002.
DOI : 10.1093/emboj/cdf381

I. Dulubova, T. Yamaguchi, D. Arac, H. Li, I. Huryeva et al., Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins, Proc. Natl. Acad. Sci. USA, pp.32-37, 2003.
DOI : 10.1073/pnas.232701299

. Licenced-copy, Copying is not permitted, except with prior permission and as allowed by law, p.32

A. Bracher and W. Weissenhorn, Structural basis for the Golgi membrane recruitment of Sly1p by Sed5p, The EMBO Journal, vol.2, issue.22, pp.6114-6124, 2002.
DOI : 10.1093/emboj/cdf608

T. Yamaguchi, I. Dulubova, S. W. Min, X. Chen, J. Rizo et al., Sly1 Binds to Golgi and ER Syntaxins via a Conserved N-Terminal Peptide Motif, Developmental Cell, vol.2, issue.3, pp.295-305, 2002.
DOI : 10.1016/S1534-5807(02)00125-9

L. N. Carpp, L. F. Ciufo, S. G. Shanks, A. Boyd, and N. J. Bryant, The Sec1p/Munc18 protein Vps45p binds its cognate SNARE proteins via two distinct modes, The Journal of Cell Biology, vol.15, issue.6, pp.927-936, 2006.
DOI : 10.1074/jbc.270.43.25328

C. F. Latham, J. A. Lopez, S. H. Hu, C. L. Gee, E. Westbury et al., Molecular Dissection of the Munc18c/Syntaxin4 Interaction: Implications for Regulation of Membrane Trafficking, Traffic, vol.117, issue.10, pp.1408-1419, 2006.
DOI : 10.1111/j.1600-0854.2006.00474.x

C. M. Carr, E. Grote, M. Munson, F. M. Hughson, and P. J. Novick, Sec1p Binds to SNARE Complexes and Concentrates at Sites of Secretion, The Journal of Cell Biology, vol.10, issue.2, pp.333-344, 1999.
DOI : 10.1074/jbc.274.9.5649

C. Rickman, C. N. Medine, A. Bergmann, and R. R. Duncan, Functionally and Spatially Distinct Modes of munc18-Syntaxin 1 Interaction, Journal of Biological Chemistry, vol.282, issue.16, pp.12097-12103, 2007.
DOI : 10.1074/jbc.M700227200

I. Dulubova, M. Khvotchev, S. Liu, I. Huryeva, T. C. Sudhof et al., Munc18-1 binds directly to the neuronal SNARE complex, Proceedings of the National Academy of Sciences, vol.104, issue.8, pp.2697-2702, 2007.
DOI : 10.1073/pnas.0611318104

M. E. Graham, J. W. Barclay, and R. D. Burgoyne, Syntaxin/Munc18 Interactions in the Late Events during Vesicle Fusion and Release in Exocytosis, Journal of Biological Chemistry, vol.279, issue.31, pp.32751-32760, 2004.
DOI : 10.1074/jbc.M400827200

L. F. Ciufo, J. W. Barclay, R. D. Burgoyne, and A. Morgan, Munc18-1 Regulates Early and Late Stages of Exocytosis via Syntaxin-independent Protein Interactions, Molecular Biology of the Cell, vol.16, issue.2, pp.470-482, 2005.
DOI : 10.1091/mbc.E04-08-0685

R. Ossig, C. Dascher, H. H. Trepte, H. D. Schmitt, and D. Gallwitz, The yeast SLY gene products, suppressors of defects in the essential GTP-binding Ypt1 protein, may act in endoplasmic reticulum-to-Golgi transport., Molecular and Cellular Biology, vol.11, issue.6, pp.2980-2993, 1991.
DOI : 10.1128/MCB.11.6.2980

L. P. Haynes, G. J. Evans, A. Morgan, and R. D. Burgoyne, -regulated Exocytosis in Neuroendocrine Cells, Journal of Biological Chemistry, vol.276, issue.13, pp.9726-9732, 2001.
DOI : 10.1074/jbc.M006959200

URL : https://hal.archives-ouvertes.fr/in2p3-00022740

J. W. Barclay, T. J. Craig, R. J. Fisher, L. F. Ciufo, G. J. Evans et al., Phosphorylation of Munc18 by Protein Kinase C Regulates the Kinetics of Exocytosis, Journal of Biological Chemistry, vol.278, issue.12, pp.10538-10545, 2003.
DOI : 10.1074/jbc.M211114200

D. A. Archer, M. E. Graham, and R. D. Burgoyne, Complexin Regulates the Closure of the Fusion Pore during Regulated Vesicle Exocytosis, Journal of Biological Chemistry, vol.277, issue.21, pp.18249-18252, 2002.
DOI : 10.1074/jbc.C200166200

M. Okamoto and T. C. Sudhof, Mints, Munc18-interacting Proteins in Synaptic Vesicle Exocytosis, Journal of Biological Chemistry, vol.272, issue.50, pp.31459-31464, 1997.
DOI : 10.1074/jbc.272.50.31459

. Licenced-copy, Copying is not permitted, except with prior permission and as allowed by law

S. Pabst, M. Margittai, D. Vainus, R. Langen, R. Jahn et al., Rapid and Selective Binding to the Synaptic SNARE Complex Suggests a Modulatory Role of Complexins in Neuroexocytosis, Journal of Biological Chemistry, vol.277, issue.10, pp.7838-7848, 2002.
DOI : 10.1074/jbc.M109507200

C. Rizo and J. , Three-dimensional structure of the complexin, Neuron, vol.33, pp.397-409, 2002.

M. E. Graham, A. W. Sudlow, and R. D. Burgoyne, Evidence Against an Acute Inhibitory Role of nSec-1 (Munc-18) in Late Steps of Regulated Exocytosis in Chromaffin and PC12 Cells, Journal of Neurochemistry, vol.69, issue.6, pp.2369-2377, 1997.
DOI : 10.1046/j.1471-4159.1997.69062369.x

D. Schutz, F. Zilly, T. Lang, R. Jahn, and D. Bruns, A dual function for Munc-18 in exocytosis of PC12 cells, European Journal of Neuroscience, vol.148, issue.9, pp.2419-2432, 2005.
DOI : 10.1111/j.1460-9568.2005.04095.x

M. E. Graham, R. J. Fisher, and R. D. Burgoyne, Measurement of exocytosis by amperometry in adrenal chromaffin cells: Effects of clostridial neurotoxins and activation of protein kinase C on fusion pore kinetics, Biochimie, vol.82, issue.5, pp.469-479, 2000.
DOI : 10.1016/S0300-9084(00)00196-6

M. E. Graham and R. D. Burgoyne, Comparison of cysteine string protein (Csp) and mutant ?-SNAP overexpression reveals a role for Csp in late steps of membrane fusion in dense-core granule exocytosis in adrenal chromaffin cells, J. Neurosci, vol.20, pp.1281-1289, 2000.

M. T. Handley, L. P. Haynes, and R. D. Burgoyne, Differential dynamics of Rab3A and Rab27A on secretory granules, Journal of Cell Science, vol.120, issue.6, pp.973-984, 2007.
DOI : 10.1242/jcs.03406

A. Martelli, G. Baldini, G. Tabellini, D. Koticha, R. Bareggi et al., Rab3A and Rab3D control the total granule number and the fraction of granules docked at the plasma membrane in PC12 cells, Traffic, vol.1, pp.976-986, 2000.

R. D. Burgoyne and T. R. Cheek, Reorganisation of peripheral actin filaments as a prelude to exocytosis, Bioscience Reports, vol.295, issue.4, pp.281-288, 1987.
DOI : 10.1007/BF01121449

R. F. Toonen, O. Kochubey, H. De-wit, A. Gulyas-kovacs, B. Konijnenburg et al., Dissecting docking and tethering of secretory vesicles at the target membrane, The EMBO Journal, vol.52, issue.16, pp.3725-3737, 2006.
DOI : 10.1038/35022500

T. Coppola, C. Frantz, V. Perret-menoud, S. Gattesco, H. Hirling et al., Pancreatic ??-Cell Protein Granuphilin Binds Rab3 and Munc-18 and Controls Exocytosis, Molecular Biology of the Cell, vol.13, issue.6, pp.1906-1915, 2002.
DOI : 10.1091/mbc.02-02-0025

T. Dresbach, M. E. Burns, V. O-'connor, W. M. Debello, H. Betz et al., A neuronal Sec1 homolog regulates neurotransmitter release at the squid giant synapse, J.Neurosci, vol.18, pp.2923-2932, 1998.

D. C. Thurmond, M. Kanzaki, A. H. Khan, and J. E. Pessin, Munc18c Function Is Required for Insulin-Stimulated Plasma Membrane Fusion of GLUT4 and Insulin-Responsive Amino Peptidase Storage Vesicles, Molecular and Cellular Biology, vol.20, issue.1, pp.379-388, 2000.
DOI : 10.1128/MCB.20.1.379-388.2000

R. R. Duncan, J. Greaves, U. K. Wiegand, I. Matskevich, G. Bodammer et al., Functional and spatial segregation of secretory vesicle pools according to vesicle age, Nature, vol.27, issue.6928, pp.176-180, 2003.
DOI : 10.1073/pnas.97.22.11984

N. Ballew, Y. Liu, and C. Barlowe, A Rab Requirement Is Not Bypassed in SLY1-20 Suppression, Molecular Biology of the Cell, vol.16, issue.4, pp.1839-1849, 2005.
DOI : 10.1091/mbc.E04-08-0725

. Licenced-copy, Copying is not permitted, except with prior permission and as allowed by law