S. Gordon, Alternative activation of macrophages, Nature Reviews Immunology, vol.3, issue.1, pp.23-35, 2003.
DOI : 10.1038/nri978

URL : https://hal.archives-ouvertes.fr/hal-00474829

R. Medzhitov, Toll-like receptors and innate immunity, Nature Reviews Immunology, vol.274, issue.2, pp.135-180, 2001.
DOI : 10.1038/35100529

B. Beutler, Limits of a deletion spanning Tlr4 in C57BL/10ScCr mice, Science, vol.282, pp.2085-88, 1998.

M. Guha and N. Mackman, LPS induction of gene expression in human monocytes, Cellular Signalling, vol.13, issue.2, pp.85-94, 2001.
DOI : 10.1016/S0898-6568(00)00149-2

S. L. Weinstein, M. R. Gold, and A. L. Defranco, Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages., Proc. Natl. Acad. Sci. USA, pp.4148-52, 1991.
DOI : 10.1073/pnas.88.10.4148

J. Hambleton, S. L. Weinstein, L. Lem, and A. L. Defranco, Activation of, 1996.

J. Han, J. D. Lee, L. Bibbs, and R. J. Ulevitch, A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells, Science, vol.265, issue.5173, pp.808-819, 1994.
DOI : 10.1126/science.7914033

Y. M. Janssen-heininger, M. E. Poynter, and P. A. Baeuerle, Recent advances torwards understanding redox mechanisms in the activation of nuclear factor ??b, Free Radical Biology and Medicine, vol.28, issue.9, pp.1317-1344, 2000.
DOI : 10.1016/S0891-5849(00)00218-5

Y. Cakir and S. W. Ballinger, Reactive Species-Mediated Regulation of Cell Signaling and the Cell Cycle: The Role of MAPK, Antioxidants & Redox Signaling, vol.7, issue.5-6, pp.726-766, 2005.
DOI : 10.1089/ars.2005.7.726

H. S. Park, H. J. Jung, E. Y. Park, J. Kim, W. J. Lee et al., Cutting Edge: Direct Interaction of TLR4 with NAD(P)H Oxidase 4 Isozyme Is Essential for Lipopolysaccharide-Induced Production of Reactive Oxygen Species and Activation of NF-??B, The Journal of Immunology, vol.173, issue.6, pp.3589-93, 2004.
DOI : 10.4049/jimmunol.173.6.3589

H. J. Forman and M. Torres, Reactive Oxygen Species and Cell Signaling, American Journal of Respiratory and Critical Care Medicine, vol.166, issue.supplement_1, pp.4-8, 2002.
DOI : 10.1164/rccm.2206007

J. D. Lambeth, NOX enzymes and the biology of reactive oxygen, Nature Reviews Immunology, vol.275, issue.3, 2004.
DOI : 10.1038/nri1312

H. Kamata and H. Hirata, Redox Regulation of Cellular Signalling, Cellular Signalling, vol.11, issue.1, pp.1-14, 1999.
DOI : 10.1016/S0898-6568(98)00037-0

C. H. Woo, J. H. Lim, K. , and J. H. , Lipopolysaccharide Induces Matrix Metalloproteinase-9 Expression via a Mitochondrial Reactive Oxygen Species-p38 Kinase-Activator Protein-1 Pathway in Raw 264.7 Cells, The Journal of Immunology, vol.173, issue.11, pp.6973-80, 2004.
DOI : 10.4049/jimmunol.173.11.6973

C. Fleury, M. Neverova, S. Collins, S. Raimbault, O. Champigny et al., Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia, Nature Genetics, vol.281, issue.3, pp.269-72, 1997.
DOI : 10.1056/NEJM199508103330605

A. Negre-salvayre, C. Hirtz, G. Carrera, R. Cazenave, M. Troly et al., A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation, FASEB J, vol.11, pp.809-824, 1997.
URL : https://hal.archives-ouvertes.fr/hal-00393579

D. Arsenijevic, H. Onuma, C. Pecqueur, S. Raimbault, B. S. Manning et al., Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production, Nat. Genet, vol.26, pp.435-474, 2000.

T. Kizaki, K. Suzuki, Y. Hitomi, N. Tanigushi, D. Saitoh et al., Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages, Proc. Natl. Acad, 2002.
DOI : 10.1073/pnas.142206299

A. M. Doulcier, The uncoupling protein 2 modulates the cytokine balance in innate immunity, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00136168

A. Tedgui, B. Miroux, and Z. Mallat, Protective role of uncoupling protein 2 in atherosclerosis, Circulation, vol.107, pp.388-90, 2003.

A. Defranco, Phosphatidylinositol 3-kinase and mTOR mediate lipopolysaccharidestimulated nitric oxide production in macrophages via interferon-beta, J. Leukoc. Biol, vol.67, pp.405-419, 2000.

K. Sandau, J. Pfeilschifter, and B. Brüne, The balance between nitric oxide and superoxide determines apoptotic and necrotic death of rat mesangial cells, J. Immunol, vol.158, pp.4938-4984, 1997.

S. Raha, R. , and B. H. , Mitochondria, oxygen free radicals, and apoptosis, American Journal of Medical Genetics, vol.384, issue.1, pp.62-70, 2001.
DOI : 10.1002/ajmg.1398

M. S. Williams and J. Kwon, T cell receptor stimulation, reactive oxygen species, and cell signaling. Free Radic, Biol. Med, vol.37, pp.1144-51, 2004.

S. H. Kim, J. Kim, and R. P. Sharma, Inhibition of p38 and ERK MAP kinases blocks endotoxin-induced nitric oxide production and differentially modulates cytokine expression, Pharmacological Research, vol.49, issue.5, pp.433-442, 2004.
DOI : 10.1016/j.phrs.2003.11.004

J. Macmicking, Q. W. Xie, N. , and C. , NITRIC OXIDE AND MACROPHAGE FUNCTION, Annual Review of Immunology, vol.15, issue.1, pp.323-50, 1997.
DOI : 10.1146/annurev.immunol.15.1.323

B. Engelhardt and H. Wolburg, Mini-review: Transendothelial migration of leukocytes: through the front door or around the side of the house?, European Journal of Immunology, vol.105, issue.11, pp.2955-63, 2004.
DOI : 10.1002/eji.200425327

C. F. Nathan, H. W. Murray, M. E. Wiebe, R. , and B. Y. , Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity, Journal of Experimental Medicine, vol.158, issue.3, pp.670-89, 1983.
DOI : 10.1084/jem.158.3.670

J. M. Woods, G. K. Haines, and I. L. , Sensitization of IFN-gamma Jak- STAT signaling during macrophage activation Manipulation of mitogen-activated protein kinase/nuclear factor-kappaB-signaling cascades during intracellular Toxoplasma gondii infection, Nat. Immunol. Immunol. Rev, vol.3, issue.201, pp.859-65, 2002.

K. Kariko, D. Weissman, W. , and F. A. , Inhibition of Toll-like Receptor and Cytokine Signaling???A Unifying Theme in Ischemic Tolerance, Journal of Cerebral Blood Flow & Metabolism, vol.68, pp.1288-304, 2004.
DOI : 10.1097/01.WCB.0000145666.68576.71