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High expression of gabarapl1 is associated with a better outcome for patients with lymph node-positive breast cancer.

Abstract : BACKGROUND: This study evaluates the relation of the early oestrogen-regulated gene gabarapl1 to cellular growth and its prognostic significance in breast adenocarcinoma. METHODS: First, the relation between GABARAPL1 expression and MCF-7 growth rate was analysed. Thereafter, by performing macroarray and reverse transcriptase quantitative-polymerase chain reaction (RT-qPCR) experiments, gabarapl1 expression was quantified in several histological breast tumour types and in a retrospective cohort of 265 breast cancers. RESULTS: GABARAPL1 overexpression inhibited MCF-7 growth rate and gabarapl1 expression was downregulated in breast tumours. Gabarapl1 mRNA levels were found to be significantly lower in tumours presenting a high histological grade, with a lymph node-positive (pN+) and oestrogen and/or progesterone receptor-negative status. In univariate analysis, high gabarapl1 levels were associated with a lower risk of metastasis in all patients (hazard ratio (HR) 4.96), as well as in pN+ patients (HR 14.96). In multivariate analysis, gabarapl1 expression remained significant in all patients (HR 3.63), as well as in pN+ patients (HR 5.65). In univariate or multivariate analysis, gabarapl1 expression did not disclose any difference in metastasis risk in lymph node-negative patients. CONCLUSIONS: Our data show for the first time that the level of gabarapl1 mRNA expression in breast tumours is a good indicator of the risk of recurrence, specifically in pN+ patients.
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https://hal.archives-ouvertes.fr/hal-00468457
Contributor : Régis Delage-Mourroux <>
Submitted on : Tuesday, March 30, 2010 - 9:00:41 PM
Last modification on : Thursday, November 12, 2020 - 9:42:07 AM

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A. Berthier, S. Seguin, A. J. Sasco, J. Y. Bobin, G. de Laroche, et al.. High expression of gabarapl1 is associated with a better outcome for patients with lymph node-positive breast cancer.. British Journal of Cancer, Cancer Research UK, 2010, 102 (6), pp.1024-31. ⟨10.1038/sj.bjc.6605568⟩. ⟨hal-00468457⟩

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