Rotaxane-based propeptides: protection and enzymatic release of a bioactive pentapeptide.

Anthony Fernandes (1) , Aurélien Viterisi (1) , Frédéric Coutrot (1, 2) , Stéphanie Potok (1) , David A. Leigh (1) , Vincent Aucagne (3) , Sébastien Papot (4)

1 The School of Chemistry
2 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]
3 CBM - Centre de biophysique moléculaire
4 SRSN - Synthèse et réactivité des substances naturelles

Mots clés: delivery systems; peptides; prodrugs; rotaxanes; supramolecular chemistry HUMAN CANCER-CELLS; SQUARAINE-DERIVED ROTAXANES; NEAR-IR DYES; MOLECULAR MACHINE; PEPTIDE ROTAXANES; AMINOPEPTIDASE-M; PRODRUG THERAPY; POLYROTAXANES; ACTIVATION; OPIOIDS

Domaines: Chimie organique

Anthony Fernandes, Aurélien Viterisi, Frédéric Coutrot, Stéphanie Potok, David A. Leigh, et al.. Rotaxane-based propeptides: protection and enzymatic release of a bioactive pentapeptide.. Angewandte Chemie International Edition, 2009, 48 (35), pp.6443-7. ⟨10.1002/anie.200903215⟩. ⟨hal-00467015⟩