Cord blood cytokines are modulated by maternal farming activities and consumption of farm dairy products during pregnancy: the PASTURE Study. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Allergy and Clinical Immunology Année : 2010

Cord blood cytokines are modulated by maternal farming activities and consumption of farm dairy products during pregnancy: the PASTURE Study.

Petra Ina Pfefferle
  • Fonction : Auteur
Gisela Büchele
  • Fonction : Auteur
Nicole Blümer
  • Fonction : Auteur
Marjut Roponen
  • Fonction : Auteur
Markus Johannes Ege
  • Fonction : Auteur
Susanne Krauss-Etschmann
  • Fonction : Auteur
Jon Genuneit
Anne Hyvärinen
  • Fonction : Auteur
Maija-Riitta Hirvonen
  • Fonction : Auteur
Roger Lauener
  • Fonction : Auteur
Juha Pekkanen
  • Fonction : Auteur
Josef Riedler
  • Fonction : Auteur
Bert Brunekeef
  • Fonction : Auteur
Charlotte Braun-Fahrländer
  • Fonction : Auteur
Erika von Mutius
  • Fonction : Auteur
Harald Renz
  • Fonction : Auteur
Non Renseigné
  • Fonction : Auteur

Résumé

BACKGROUND: Traditional farming represents a unique model situation to investigate the relationship of early-life farm-related exposure and allergy protection. OBJECTIVES: To investigate associations between maternal farm exposures and cytokine production in cord blood (CB) mononuclear cells in a prospective multinational birth cohort of 299 farm and 326 nonfarm children and their families. METHODS: Supernatants from phorbol 12-myristate 13-acetate/ionomycin-stimulated CB mononuclear cells were assessed for the production of IFN-gamma, TNF-alpha, IL-5, IL-10, and IL-12. RESULTS: Significantly higher levels of IFN-gamma and TNF-alpha in farm compared with nonfarm children were found, whereas IL-5, IL-10, and IL-12 levels did not differ between study groups. Maternal contact with different farm animal species and barns and consumption of farm-produced butter during pregnancy enhanced the production of proinflammatory CB cytokines, whereas maternal consumption of farm-produced yogurt resulted in significant lower levels of IFN-gamma and TNF-alpha in umbilical blood. CONCLUSION: Maternal exposure to farming activities and farm dairy products during pregnancy modulated cytokine production patterns of offspring at birth.

Dates et versions

hal-00462276 , version 1 (09-03-2010)

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Citer

Petra Ina Pfefferle, Gisela Büchele, Nicole Blümer, Marjut Roponen, Markus Johannes Ege, et al.. Cord blood cytokines are modulated by maternal farming activities and consumption of farm dairy products during pregnancy: the PASTURE Study.. Journal of Allergy and Clinical Immunology, 2010, 125 (1), pp.108-15.e1-3. ⟨10.1016/j.jaci.2009.09.019⟩. ⟨hal-00462276⟩
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