A simple method for detection of major phenotypic abnormalities in myelodysplastic syndromes: expression of CD56 in CMML.

Charlotte Lacronique-Gazaille , Marie-Pierre Chaury , Alexandre Le Guyader (1) , Jean-Luc Faucher (2) , Dominique Bordessoule (2, 3, 4) , Jean Feuillard (5)

1 Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges]
2 Service d'Hématologie biologique [CHU Limoges]
3 Service d'Hématologie clinique et thérapie cellulaire [CHU Limoges]
4 UNILIM - Université de Limoges
5 PMRIL - Physiologie Moléculaire de la Réponse Immune et des Lymphoproliférations

Using a very simple flow cytometry protocol, we found that CD36 and CD117 on granulocytes and CD56 on monocytes were the major bone marrow phenotypic aberrations in patients with myelodysplasia, including CMML. CD56 on monocytes was associated with CMML. Importantly, phenotypic aberrations were lost on blood cells, except for CD56.

Domaines: Immunologie

Charlotte Lacronique-Gazaille, Marie-Pierre Chaury, Alexandre Le Guyader, Jean-Luc Faucher, Dominique Bordessoule, et al.. A simple method for detection of major phenotypic abnormalities in myelodysplastic syndromes: expression of CD56 in CMML.. Haematologica, 2007, 92 (6), pp.859-60. ⟨hal-00451224⟩