Geraniol restores antibiotic activities against multi-drug resistant isolates from Gram-negative species

V. Lorenzi , A. Muselli (1) , A.F. Bernardini (1) , L. Berti (1) , J.M. Pagès , L. Amaral , J.M. Bolla

1 SPE - Sciences pour l'environnement

The essential oil of Helichrysum italicum significantly reduces multidrug resistance of Enterobacter aerogenes, Escherichia coli, Pseudomonas aeruginosa and Acinetobacter baumannii. Combinations of the two most active fractions of the essential oil with each other or with phenylalanine arginine β-naphthylamide yield synergistic activity. Geraniol a component of one fraction significantly increased the efficacy of ß-Lactams, quinolones and chloramphenicol.

Domaines: Chimie organique

V. Lorenzi, A. Muselli, A.F. Bernardini, L. Berti, J.M. Pagès, et al.. Geraniol restores antibiotic activities against multi-drug resistant isolates from Gram-negative species. Antimicrobial Agents and Chemotherapy, 2009, 53(5), pp.2209-2211. ⟨hal-00449646⟩