Preparation of inclusion complex of piroxicam with cyclodextrin by using supercritical carbon dioxide

Martial Sauceau (1) , Élisabeth Rodier (1) , Jacques Fages (1)

1 RAPSODEE - Centre de recherche d'Albi en génie des procédés des solides divisés, de l'énergie et de l'environnement

Forming complexes with cyclodextrins can enhance the dissolution rate, the stability, the solubility and the bioavailability of a drug. In this work, piroxicam/β-cyclodextrin complexes were prepared at solid state by means of supercritical carbon dioxide. The influence of temperature, residence time, water content and a ternary agent, L-lysine, were studied. The complex was characterized by Differential Scanning Calorimetry, Scanning Electronic Microscope and dissolution profile in water. Finally, a complete inclusion was achieved for a piroxicam/β-cyclodextrin/L-lysine mixture by keeping a physical mixture of the three compounds (1:2:1.5 molar ratio) for 2 hours in contact with CO2 at 150°C and 15 MPa.

Mots clés: piroxicam; complex; cyclodextrin; supercritical carbon dioxide; ternary agent

Domaines: Autre; Génie des procédés; Pharmacie galénique

Martial Sauceau, Élisabeth Rodier, Jacques Fages. Preparation of inclusion complex of piroxicam with cyclodextrin by using supercritical carbon dioxide. Journal of Supercritical Fluids, 2008, 47 (2), pp.326-332. ⟨10.1016/j.supflu.2008.07.006⟩. ⟨hal-00441530v2⟩