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Translational control of localized mRNAs: restricting protein synthesis in space and time.

Abstract : As highlighted by recent genome-wide analyses in diverse organisms and cell types, subcellular targeting of mRNAs has emerged as a major mechanism for cells to establish functionally distinct compartments and structures. For protein synthesis to be spatially restricted, translation of localizing mRNAs is silenced during their transport and is activated when they reach their final destination. Such a precise translation pattern is controlled by repressors, which are specifically recruited to transport ribonucleoprotein particles and block translation at different steps. Functional studies have revealed that the inactivation of these repressors, either by pre-localized proteins or in response to conserved signalling pathways, triggers local protein synthesis.
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https://hal.archives-ouvertes.fr/hal-00437646
Contributor : Yvette Benhamou Connect in order to contact the contributor
Submitted on : Tuesday, December 1, 2009 - 10:55:07 AM
Last modification on : Thursday, August 4, 2022 - 5:06:57 PM

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Florence Besse, Anne Ephrussi. Translational control of localized mRNAs: restricting protein synthesis in space and time.. Nature Reviews Molecular Cell Biology, Nature Publishing Group, 2008, 9 (12), pp.971-80. ⟨10.1038/nrm2548⟩. ⟨hal-00437646⟩

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