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Article Dans Une Revue Optics Express Année : 2009

Optical-fiber-microsphere for remote fluorescence correlation spectroscopy

H. Aouani
  • Fonction : Auteur
Jérôme Wenger
Patrick Ferrand
H. Rigneault

Résumé

Fluorescence correlation spectroscopy (FCS) is a versatile method that would greatly benefit to remote optical-fiber fluorescence sensors. However, the current state-of-the-art struggles with high background and low detection sensitivities that prevent the extension of fiber-based FCS down to the single-molecule level. Here we report the use of an optical fiber combined with a latex microsphere to perform FCS analysis. The sensitivity of the technique is demonstrated at the single molecule level thanks to a photonic nanojet effect. This offers new opportunities for reducing the bulky microscope setup and extending FCS to remote or in vivo applications.
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Dates et versions

hal-00430201 , version 1 (26-09-2015)

Identifiants

Citer

H. Aouani, F. Deiss, Jérôme Wenger, Patrick Ferrand, N. Sojic, et al.. Optical-fiber-microsphere for remote fluorescence correlation spectroscopy. Optics Express, 2009, 17 (21), pp.19085-19092. ⟨10.1364/OE.17.019085⟩. ⟨hal-00430201⟩
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