Dombrock genotyping in a native Congolese cohort reveals two novel alleles
Résumé
The Dombrock (DO) blood group system comprises two major antithetical antigens: Doa (DO1, ISBT 014001) and Dob (DO2, ISBT 014002), and three high-prevalence antigens, Gregory (Gya; DO3, ISBT 014003), Holley (Hy; DO4, ISBT 014004), and Joseph (Joa; DO5, ISBT 014005). Tests using anti-Doa and anti-Dob in different ethnic groups have shown phenotypic variations in the prevalence of these antigens.1-5 The DOB allele has been slightly more prevalent than the DOA allele in all human populations studied thus far.6 The absence of high-prevalence antigens Hy and Joa in Gy(a+) individuals has been observed only in individuals of African ancestry. A close phenotypic relationship has been observed between Gya and Hy antigens because Gy(a-) red blood cells (RBCs) from Caucasians are Hy-negative, and Hy-negative RBCs from African Americans are Gy(a+w).7-9