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Four newly isolated fuselloviruses from extreme geothermal environments reveal unusual morphologies and a possible interviral recombination mechanism.

Abstract : Spindle-shaped virus-like particles are abundant in extreme geothermal environments, from which five spindle-shaped viral species have been isolated to date. They infect members of the hyperthermophilic archaeal genus Sulfolobus, and constitute the Fuselloviridae, a family of double-stranded DNA viruses. Here we present four new members of this family, all from terrestrial acidic hot springs. Two of the new viruses exhibit a novel morphotype for their proposed attachment structures, and specific features of their genome sequences strongly suggest the identity of the host-attachment protein. All fuselloviral genomes are highly conserved at the nucleotide level, although the regions of conservation differ between virus-pairs, consistent with a high frequency of homologous recombination having occurred between them. We propose a fuselloviral specific mechanism for interviral recombination, and show that the spacers of the Sulfolobus CRISPR antiviral system are not biased to the highly similar regions of the fusellovirus genomes.
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https://hal.archives-ouvertes.fr/hal-00408953
Contributor : Marie-Claude Serre <>
Submitted on : Tuesday, August 4, 2009 - 3:29:33 PM
Last modification on : Saturday, July 3, 2021 - 3:39:55 AM

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Peter Redder, Xu Peng, Kim Brügger, Shiraz A Shah, Ferdinand Roesch, et al.. Four newly isolated fuselloviruses from extreme geothermal environments reveal unusual morphologies and a possible interviral recombination mechanism.. Environmental Microbiology, Society for Applied Microbiology and Wiley-Blackwell, 2009, epub ahead of print. ⟨10.1111/j.1462-2920.2009.02009.x⟩. ⟨hal-00408953⟩

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