Smart magnetic resonance imaging agents that sense extracellular calcium fluctuations

Abstract : Image brain function: Gd3+ chelates linked to a modified EGTA moiety were prepared in order to respond to extracellular Ca2+ fluctuations in the brain. Upon interaction with Ca2+, they exhibit high and reversible relaxivity changes in buffered solution or in a model of the brain extracellular medium. These efficient Ca2+ magnetic resonance imaging sensors might open new perspectives in functional molecular imaging.
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https://hal.archives-ouvertes.fr/hal-00407967
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Submitted on : Tuesday, July 28, 2009 - 10:47:19 AM
Last modification on : Tuesday, March 26, 2019 - 5:52:06 PM

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Goran Angelovski, Petra Fouskova, Ilgar Mamedov, Santiago Canals, Eva Toth, et al.. Smart magnetic resonance imaging agents that sense extracellular calcium fluctuations. ChemBioChem, Wiley-VCH Verlag, 2008, 9 (11), pp.1729-34. ⟨10.1002/cbic.200800165⟩. ⟨hal-00407967⟩

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