MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2009

MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells.

Résumé

In response to inflammatory stimulation, dendritic cells (DCs) have a remarkable pattern of differentiation (maturation) that exhibits specific mechanisms to control immunity. Here, we show that in response to Lipopolysaccharides (LPS), several microRNAs (miRNAs) are regulated in human monocyte-derived dendritic cells. Among these miRNAs, miR-155 is highly up-regulated during maturation. Using LNA silencing combined to microarray technology, we have identified the Toll-like receptor/interleukin-1 (TLR/IL-1) inflammatory pathway as a general target of miR-155. We further demonstrate that miR-155 directly controls the level of TAB2, an important signal transduction molecule. Our observations suggest, therefore, that in mature human DCs, miR-155 is part of a negative feedback loop, which down-modulates inflammatory cytokine production in response to microbial stimuli.

Domaines

Immunologie

Dates et versions

hal-00407802 , version 1 (27-07-2009)

Identifiants

Citer

Maurizio Ceppi, Patricia M Pereira, Isabelle Dunand-Sauthier, Emmanuèle Barras, Walter Reith, et al.. MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells.. Proceedings of the National Academy of Sciences of the United States of America, 2009, 106 (8), pp.2735-40. ⟨10.1073/pnas.0811073106⟩. ⟨hal-00407802⟩

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