Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009.

G. Kroemer (1) , L. Galluzzi (1) , P. Vandenabeele (2) , J. Abrams (3) , Emad S Alnemri (4) , E. H. Baehrecke (5) , M. V. Blagosklonny (6) , W. S. El-Deiry (7) , P. Golstein (8) , D. R. Green (9) , M. Hengartner (10) , R. A. Knight (11) , S. Kumar (12) , S. A. Lipton (13) , W. Malorni (14) , G. Nuñez (15) , M. E. Peter (16) , J. Tschopp (17) , J. Yuan (18) , M. Piacentini (19) , B. Zhivotovsky (20) , G. Melino (21, 22)

1 IGR - Institut Gustave Roussy
2 Department for Molecular Biomedical Research
3 Department of Cell Biology
4 Department of Biochemistry and Molecular Biology
5 Department of Cancer Biology
6 RPCI - Roswell Park Cancer Institute [Buffalo]
7 Hematology-Oncology Division
8 CIML - Centre d'Immunologie de Marseille - Luminy
9 Department of Immunology
10 UZH - Universität Zürich [Zürich] = University of Zurich
11 UCL - University College of London [London]
12 IMVS - Institute of Medical and Veterinary Science, Adelaide
13 UC San Diego - University of California [San Diego]
14 ISS - Istituto Superiore di Sanità = National Institute of Health
15 University of Michigan Medical School [Ann Arbor]
16 Ben May Department for Cancer Research
17 Department of Biochemistry [Lausanne]
18 Key Laboratory of the Ministry of Education on Nanomaterials
19 Laboratory of Cell Biology
20 Department of Medical Biochemistry and Biophysics
21 Biochemistry Laboratory, IDI-IRCCS, Roma
22 MRC Toxicology Unit

Different types of cell death are often defined by morphological criteria, without a clear reference to precise biochemical mechanisms. The Nomenclature Committee on Cell Death (NCCD) proposes unified criteria for the definition of cell death and of its different morphologies, while formulating several caveats against the misuse of words and concepts that slow down progress in the area of cell death research. Authors, reviewers and editors of scientific periodicals are invited to abandon expressions like 'percentage apoptosis' and to replace them with more accurate descriptions of the biochemical and cellular parameters that are actually measured. Moreover, at the present stage, it should be accepted that caspase-independent mechanisms can cooperate with (or substitute for) caspases in the execution of lethal signaling pathways and that 'autophagic cell death' is a type of cell death occurring together with (but not necessarily by) autophagic vacuolization. This study details the 2009 recommendations of the NCCD on the use of cell death-related terminology including 'entosis', 'mitotic catastrophe', 'necrosis', 'necroptosis' and 'pyroptosis'.

Domaines: Immunologie

G. Kroemer, L. Galluzzi, P. Vandenabeele, J. Abrams, Emad S Alnemri, et al.. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009.. Cell Death and Differentiation, 2009, 16 (1), pp.3-11. ⟨10.1038/cdd.2008.150⟩. ⟨hal-00407686⟩