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Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin.

Abstract : NKp46+CD3- natural killer lymphocytes isolated from blood, lymphoid organs, lung, liver and uterus can produce granule-dependent cytotoxicity and interferon-gamma. Here we identify in dermis, gut lamina propria and cryptopatches distinct populations of NKp46+CD3- cells with a diminished capacity to degranulate and produce interferon-gamma. In the gut, expression of the transcription factor RORgammat, which is involved in the development of lymphoid tissue-inducer cells, defined a previously unknown subset of NKp46+CD3- lymphocytes. Unlike RORgammat- lamina propria and dermis natural killer cells, gut RORgammat+NKp46+ cells produced interleukin 22. Our data show that lymphoid tissue-inducer cells and natural killer cells shared unanticipated similarities and emphasize the heterogeneity of NKp46+CD3- cells in innate immunity, lymphoid organization and local tissue repair.
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https://hal.archives-ouvertes.fr/hal-00403251
Contributor : Marie Laure Haon <>
Submitted on : Thursday, July 9, 2009 - 5:55:49 PM
Last modification on : Thursday, September 16, 2021 - 9:12:02 AM

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Carmelo Luci, Ana Reynders, Ivaylo I Ivanov, Celine Cognet, Laurent Chiche, et al.. Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin.. Nature Immunology, Nature Publishing Group, 2009, 10 (1), pp.75-82. ⟨10.1038/ni.1681⟩. ⟨hal-00403251⟩

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