Biomimetic doxorubicin loaded polymersomes from hyaluronan-block-poly(gamma-benzyl glutamate) copolymers

Abstract : Using "click chemistry" as an easy and versatile synthetic strategy to combine hyaluronan and polyglutamate blocks, we have prepared nanovesicles (polymersomes) that present a controlled size, excellent colloidal stability, and a high loading capacity for hydrophilic and hydrophobic drugs. The unique feature of our concept is the use of hyaluronan, a polysaccharide with known capacity for targeting cancer-related protein receptors, as the hydrophilic portion of a block copolymer system. The cytotoxicity and internalization mechanism of doxorubicin-loaded polymersomes have been evaluated in C6 glioma tumor cell lines. The dual purpose served by hyaluronan, as both a hydrophilic block critical to vesicle formation and as a binding agent for biological targets, breaks new ground in terms of multifunctional nanomaterial design for drug delivery.
Document type :
Journal articles
Complete list of metadatas

https://hal.archives-ouvertes.fr/hal-00400384
Contributor : Dominique Richard <>
Submitted on : Tuesday, June 30, 2009 - 4:12:42 PM
Last modification on : Thursday, January 11, 2018 - 6:28:10 AM

Identifiers

Collections

Citation

Kamal Kumar Upadhyay, Jean-François Le Meins, A. Misra, Pierre Voisin, Véronique Bouchaud, et al.. Biomimetic doxorubicin loaded polymersomes from hyaluronan-block-poly(gamma-benzyl glutamate) copolymers. Biomacromolecules, American Chemical Society, 2009, 10 (10), pp.2802-2808. ⟨10.1021/bm9006419⟩. ⟨hal-00400384⟩

Share

Metrics

Record views

158