Decreased blood pressure in NOX1-deficient mice.

Gaetan Gavazzi (1) , Botond Banfi , Christine Deffert , Laurence Fiette (2) , Michela Schappi , Francois Herrmann , Karl-Heinz Krause

1 UNIMIB - Università degli Studi di Milano-Bicocca = University of Milano-Bicocca
2 Histotechnologie et Pathologie

To understand the role of the superoxide-generating NADPH oxidase NOX1 in the vascular system, we have generated NOX1-deficient mice. NOX1-deficient mice had a moderately decreased basal blood pressure. In response to angiotensin II they showed an almost complete loss of the sustained blood pressure response, while the initial increase was conserved. NOX1-deficient mice showed a marked reduction in aortic media hypertrophy. Angiotensin II-induced smooth muscle cell proliferation was conserved, but there was a marked decrease in extracellular matrix accumulation. Our results establish a role for NOX1 in blood pressure regulation and vascular angiotensin II response.

Domaines: Autre [q-bio.OT]

Gaetan Gavazzi, Botond Banfi, Christine Deffert, Laurence Fiette, Michela Schappi, et al.. Decreased blood pressure in NOX1-deficient mice.. FEBS Letters, 2006, 580 (2), pp.497-504. ⟨10.1016/j.febslet.2005.12.049⟩. ⟨hal-00400060⟩