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Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease.

Abstract : In a prospective, randomised single-blinded secondary prevention trial we compared the effect of a Mediterranean alpha-linolenic acid-rich diet to the usual post-infarct prudent diet. After a first myocardial infarction, patients were randomly assigned to the experimental (n = 302) or control group (n = 303). Patients were seen again 8 weeks after randomisation, and each year for 5 years. The experimental group consumed significantly less lipids, saturated fat, cholesterol, and linoleic acid but more oleic and alpha-linolenic acids confirmed by measurements in plasma. Serum lipids, blood pressure, and body mass index remained similar in the 2 groups. In the experimental group, plasma levels of albumin, vitamin E, and vitamin C were increased, and granulocyte count decreased. After a mean follow up of 27 months, there were 16 cardiac deaths in the control and 3 in the experimental group; 17 non-fatal myocardial infarction in the control and 5 in the experimental groups: a risk ratio for these two main endpoints combined of 0.27 (95% CI 0.12-0.59, p = 0.001) after adjustment for prognostic variables. Overall mortality was 20 in the control, 8 in the experimental group, an adjusted risk ratio of 0.30 (95% CI 0.11-0.82, p = 0.02). An alpha-linolenic acid-rich Mediterranean diet seems to be more efficient than presently used diets in the secondary prevention of coronary events and death.
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Contributor : Patricia Salen Connect in order to contact the contributor
Submitted on : Monday, June 15, 2009 - 4:28:23 PM
Last modification on : Tuesday, May 17, 2022 - 2:58:09 PM


  • HAL Id : hal-00395487, version 1
  • PUBMED : 7911176


M. de Lorgeril, S. Renaud, N. Mamelle, P. Salen, J. L. Martin, et al.. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease.. The Lancet, Elsevier, 1994, 343 (8911), pp.1454-9. ⟨hal-00395487⟩



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