Use of natural monomer in the synthesis of nano- and microparticles of polyurethane by suspension-polyaddition technique

Abstract : Polyurethane nano- and microparticles were synthesized by suspension-polyaddition technique, using aqueous polymerization medium. Castor oil, a vegetable triglyceride possessing hydroxyl groups was used as natural polyol and methylene cliphenyl diisocyanate (MDI) as isocyanate. The levofloxacin, an antibacterial drug was used as model drug to measure the particles encapsulation efficiency. The effect of the addition of a second polyol, the poly(ethylene glycol) (PEG), and the stirring rate on the mean diameter and morphology of particles was also investigated. The poly(ethylene glycol) has an important effect in the reduction of particles size and their porosity. On the other hand, the poly(ethylene glycol) reduced the yield of encapsulation from 70% for the formulation without PEG to 20% for formulations with PEG. FTIR analysis confirmed the polyurethane formation. Dynamic light scattering study, transmission electron microscopy (TEM) and scanning electron microscopy (SEM) were used to determine the nanoparticles size and shape. Spectrofluorimetric analysis was used to detect the levofloxacin.
Document type :
Journal articles
Complete list of metadatas

https://hal.archives-ouvertes.fr/hal-00394467
Contributor : Dominique Richard <>
Submitted on : Thursday, June 11, 2009 - 5:50:32 PM
Last modification on : Thursday, January 11, 2018 - 6:28:09 AM

Links full text

Identifiers

Collections

Citation

Betina G. Zanetti-Ramos, Valdir Soldi, Elenara Lemos-Senna, Redouane Borsali. Use of natural monomer in the synthesis of nano- and microparticles of polyurethane by suspension-polyaddition technique. Macromolecular Symposia, Wiley-VCH Verlag, 2005, 229, pp.234-245. ⟨10.1002/masy.200551129⟩. ⟨hal-00394467⟩

Share

Metrics

Record views

71