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A concanavalin A-like lectin domain in the CHS1/LYST protein, shared by members of the BEACH family

Abstract : CHS1/LYST, the causative protein of the Chediak–Higashi syndrome (CHS), belongs to the BEACH (named after BEige And Chediak– Higashi) family, which includes various large proteins sharing the same C-terminal domain architecture [a PH (Pleckstrin homology)– BEACH domain followed by WD repeats). Members of the BEACH family are generally defined as vesicle-trafficking regulatory proteins, but their functions remain to be determined at the molecular level. Here, using a panel of sensitive methods of sequence analysis, we show that the N-terminal regions of BEACH proteins contain an as yet not described domain, which shares striking similarities with clostridial neurotoxins and defines a novel family within the concanavalin A (ConA)-like lectin superfamily. These results suggest that the BEACH ConA-like lectin domain could be involved in oligosaccharide binding associated with protein traffic and sorting along the secretory pathway, especially in relation with components of the vesicle fusion machinery.
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https://hal.archives-ouvertes.fr/hal-00383218
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Submitted on : Tuesday, May 12, 2009 - 2:09:58 PM
Last modification on : Tuesday, September 28, 2021 - 5:20:18 PM

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Agathe Burgess, Jean-Paul Mornon, Geneviève de Saint-Basile, Isabelle Callebaut. A concanavalin A-like lectin domain in the CHS1/LYST protein, shared by members of the BEACH family. Bioinformatics, Oxford University Press (OUP), 2009, 25 (10), pp.1219-1222. ⟨10.1093/bioinformatics/btp151⟩. ⟨hal-00383218⟩

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