Space-time segmentation using level set active contours applied to myocardial gated SPECT

Abstract : This paper presents a new variational method for the segmentation of a moving object against a still background, over a sequence of (2-D or 3-D) image frames. The method is illustrated in application to myocardial gated SPECT data, and incorporates a level set framework to handle topological changes while providing closed boundaries. The key innovation is the introduction of a geometrical constraint into the derivation of the Euler-Lagrange equations, such that the segmentation of each individual frame can be interpreted as a closed boundary of an object (an isolevel of a set of hyper-surfaces) while integrating information over the entire sequence. This results in the definition of an evolution velocity normal to the object boundary. Applying this method to 3-D myocardial gated SPECT sequences, the left ventricle endocardial and epicardial limits can be computed in each frame. This space-time segmentation method was tested on simulated and clinical 3-D myocardial gated SPECT sequences and the corresponding ejection fractions were computed.
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IEEE Transactions on Medical Imaging, Institute of Electrical and Electronics Engineers, 2001, 20 (7), pp.643-659. <10.1109/42.932748>
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Eric Debreuve, Michel Barlaud, Gilles Aubert, Ivan Laurette, Jacques Darcourt. Space-time segmentation using level set active contours applied to myocardial gated SPECT. IEEE Transactions on Medical Imaging, Institute of Electrical and Electronics Engineers, 2001, 20 (7), pp.643-659. <10.1109/42.932748>. <hal-00367622>

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