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Journal articles
Transcriptional repression of microRNA genes by PML-RARA increases expression of key cancer proteins in acute promyelocytic leukemia.
Anne Saumet
1
Guillaume Vetter
2
Manuella Bouttier
3
Elodie Portales-Casamar
4
Wyeth W Wasserman
4
Thomas Maurin
5
Bernard Mari
5
Pascal Barbry
5
Laurent Vallar
6
Evelyne Friederich
2
Khalil Arar
7
Bruno Cassinat
7
Christine Chomienne
8
Charles-Henri Lecellier
3, *
*
Corresponding author
Anne Saumet 1
Author
Guillaume Vetter 2
Author
Manuella Bouttier 3
Author
Elodie Portales-Casamar 4
Author
Wyeth W Wasserman 4
Author
Thomas Maurin 5
Author
Bernard Mari 5
Author IdHAL : bernard-mari ResearcherId : http://www.researcherid.com/rid/Q-5832-2019 ORCID : https://orcid.org/0000-0002-0422-9182
Pascal Barbry 5
Author IdHAL : pascal-barbry IdRef : https://www.idref.fr/088456323 ORCID : https://orcid.org/0000-0001-9632-6483
Christine Chomienne 8
Author
Charles-Henri Lecellier 3
Correspondent author
1
IGH - Institut de génétique humaine (institut de Génétique humaine 141 Rue de la Cardonille 34396 MONTPELLIER CEDEX 5 - France)
- UM - Université de Montpellier : UMR 9002 (163 rue Auguste Broussonnet - 34090 Montpellier - France)
- CNRS - Centre National de la Recherche Scientifique : UPR1142 (France)
2
Cytoskeleton and Cell Plasticity Lab (Life Sciences Research Unit-FSTC, L-1511 Luxembourg - Luxembourg)
- Uni.lu - Université du Luxembourg (6 rue Richard Coudenhove-Kalergi - L-1359 Luxembourg - Luxembourg)
3
IGMM - Institut de Génétique Moléculaire de Montpellier (1919 Route de Mende - 34293 Montpellier Cedex 5 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR5535 (France)
- UM - Université de Montpellier (163 rue Auguste Broussonnet - 34090 Montpellier - France)
4
UBC - University of British Columbia (Vancouver Campus, , 2329 West Mall, Vancouver, BC, V6T 1Z4 /
Okanagan Campus, 3333 University Way, Kelowna, BC, V1V 1V7 - Canada)
5
IPMC - Institut de pharmacologie moléculaire et cellulaire (CNRS-IPMC 660 Route des lucioles 06560 VALBONNE - France)
- UNS - Université Nice Sophia Antipolis (... - 2019) (Parc Valrose - BP 2135 - 06103 Nice cedex 2 - France)
- COMUE UCA - COMUE Université Côte d'Azur (2015 - 2019) (Parc Valrose, 28 avenue Valrose 06108 Nice Cedex 2 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR6097 (France)
8
UMR_S_718 - Granulopoiese et Processus Leucemiques (Hopital Saint-Louis PARIS VII 1, Avenue Claude Vellefaux 75475 PARIS CEDEX 10 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U718 (101, rue de Tolbiac, 75013 Paris - France)
- UPD7 - Université Paris Diderot - Paris 7 (5 rue Thomas-Mann - 75205 Paris cedex 13 - France)
Abstract : Micro(mi)RNAs are small noncoding RNAs that orchestrate many key aspects of cell physiology and their deregulation is often linked to distinct diseases including cancer. Here, we studied the contribution of miRNAs in a well-characterized human myeloid leukemia, acute promyelocytic leukemia (APL), targeted by retinoic acid and trioxide arsenic therapy. We identified several miRNAs transcriptionally repressed by the APL-associated PML-RAR oncogene which are released after treatment with all-trans retinoic acid. These coregulated miRNAs were found to control, in a coordinated manner, crucial pathways linked to leukemogenesis, such as HOX proteins and cell adhesion molecules whose expressions are thereby repressed by the chemotherapy. Thus, APL appears linked to transcriptional perturbation of miRNA genes, and clinical protocols able to successfully eradicate cancer cells may do so by restoring miRNA expression. The identification of abnormal miRNA biogenesis in cancer may therefore provide novel biomarkers and therapeutic targets in myeloid leukemias.
Document type :
Journal articles
Complete list of metadatas
https://hal.archives-ouvertes.fr/hal-00367055
Contributor : Sylvie Julien <>
Submitted on : Tuesday, March 10, 2009 - 11:36:53 AM
Last modification on : Friday, December 18, 2020 - 5:30:02 PM
Contributor : Sylvie Julien <>
Submitted on : Tuesday, March 10, 2009 - 11:36:53 AM
Last modification on : Friday, December 18, 2020 - 5:30:02 PM
Identifiers
- HAL Id : hal-00367055, version 1
- DOI : 10.1182/blood-2008-05-158139
- PUBMED : 18941112
Collections
UNICE | CNRS | UNIV-PARIS7 | USPC | BS | UNIV-MONTPELLIER | UNIV-COTEDAZUR | UNIV-PARIS
Citation
Anne Saumet, Guillaume Vetter, Manuella Bouttier, Elodie Portales-Casamar, Wyeth W Wasserman, et al.. Transcriptional repression of microRNA genes by PML-RARA increases expression of key cancer proteins in acute promyelocytic leukemia.. Blood, American Society of Hematology, 2009, 113 (2), pp.412-21. ⟨10.1182/blood-2008-05-158139⟩. ⟨hal-00367055⟩
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