Chicoric acid, a new compound able to enhance insulin release and glucose uptake.

Didier Tousch (1) , Anne-Dominique Lajoix (1) , Eric Hosy , Jacqueline Azay-Milhau (1) , Karine Ferrare (1) , Céline Jahannault (1) , Gérard Cros (1) , Pierre Petit (1)

1 CPID - Centre de pharmacologie et innovation dans le diabète

Caffeic acid and chlorogenic acid (CGA), a mono-caffeoyl ester, have been described as potential antidiabetic agents. Using in vitro studies, we report the effects of a dicaffeoyl ester, chicoric acid (CRA) purified from Cichorium intybus, on glucose uptake and insulin secretion. Our results show that CRA and CGA increased glucose uptake in L6 muscular cells, an effect only observed in the presence of stimulating concentrations of insulin. Moreover, we found that both CRA and CGA were able to stimulate insulin secretion from the INS-1E insulin-secreting cell line and rat islets of Langerhans. In the later case, the effect of CRA is only observed in the presence of subnormal glucose levels. Patch clamps studies show that the mechanism of CRA and CGA was different from that of sulfonylureas, as they did not close K(ATP) channels. Chicoric acid is a new potential antidiabetic agent carrying both insulin sensitizing and insulin-secreting properties.

Domaines: Endocrinologie et métabolisme

Didier Tousch, Anne-Dominique Lajoix, Eric Hosy, Jacqueline Azay-Milhau, Karine Ferrare, et al.. Chicoric acid, a new compound able to enhance insulin release and glucose uptake.. Biochemical and Biophysical Research Communications, 2008, 377 (1), pp.131-5. ⟨10.1016/j.bbrc.2008.09.088⟩. ⟨hal-00358429⟩