Synthesis and Self-Assembly Properties of Peptide-Polylactide Block Copolymers

Sylvain Caillol (1) , Sébastien Lecommandoux (2) , Anne-Françoise Mingotaud (3) , Michèle Schappacher (2) , Alain Soum (2) , Nathan Bryson , Rémi Meyrueix

1 ICGM ICMMM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier
2 LCPO - Laboratoire de Chimie des polymères organiques
3 IMRCP - Interactions moléculaires et réactivité chimique et photochimique

Poly(L-lactide-b-gamma-benzyl glutamate) copolymers with various block lengths were synthesized by sequential ring-opening polymerization of L-lactide and N-carboxyanhydride of gamma-benzyl glutamate. The copolymers were characterized by SEC and NMR spectrometry. DSC and SAXS data suggested that the copolymers were phase-separated in domains containing either crystalline PLLA or liquid-crystalline columnar hexagonal morphology of PBLG. When varying the temperature, reversible local order-order transition could be observed on these diblock copolymers.

Mots clés: SUPRAMOLECULAR MATERIALS; N-CARBOXYANHYDRIDES; POLYMERS

Domaines: Polymères

Sylvain Caillol, Sébastien Lecommandoux, Anne-Françoise Mingotaud, Michèle Schappacher, Alain Soum, et al.. Synthesis and Self-Assembly Properties of Peptide-Polylactide Block Copolymers. Macromolecules, 2003, 36 (4), pp.1118-1124. ⟨10.1021/ma021187c⟩. ⟨hal-00356176⟩