tRNAdb 2009: compilation of tRNA sequences and tRNA genes.

Frank Jühling (1) , Mario Mörl (2) , Roland K Hartmann (3) , Mathias Sprinzl (4) , Peter F Stadler (1) , Joern Pütz (5)

1 Bioinformatics Group - University of Leipzig
2 Institute for Biochemistry - University of Leipzig
3 Philipps Universität Marburg = Philipps University of Marburg
4 Universität Bayreuth
5 ARN - Architecture et réactivité de l'ARN

One of the first specialized collections of nucleic acid sequences in life sciences was the 'compilation of tRNA sequences and sequences of tRNA genes' (http://www.trna.uni-bayreuth.de). Here, an updated and completely restructured version of this compilation is presented (http://trnadb.bioinf.uni-leipzig.de). The new database, tRNAdb, is hosted and maintained in cooperation between the universities of Leipzig, Marburg, and Strasbourg. Reimplemented as a relational database, tRNAdb will be updated periodically and is searchable in a highly flexible and user-friendly way. Currently, it contains more than 12 000 tRNA genes, classified into families according to amino acid specificity. Furthermore, the implementation of the NCBI taxonomy tree facilitates phylogeny-related queries. The database provides various services including graphical representations of tRNA secondary structures, a customizable output of aligned or un-aligned sequences with a variety of individual and combinable search criteria, as well as the construction of consensus sequences for any selected set of tRNAs.

Domaines: Biochimie, Biologie Moléculaire; Biologie cellulaire

Frank Jühling, Mario Mörl, Roland K Hartmann, Mathias Sprinzl, Peter F Stadler, et al.. tRNAdb 2009: compilation of tRNA sequences and tRNA genes.. Nucleic Acids Research, 2009, 37 (Database issue), pp.D159-62. ⟨10.1093/nar/gkn772⟩. ⟨hal-00356160⟩