Skip to Main content Skip to Navigation
Journal articles

Antiplasmodial alkaloids from Desmos rostrata.

Abstract : Two new alkaloids, desmorostratine (1) and discretine N-oxide (2), were isolated from the stem bark of Desmos rostrata, together with five known alkaloids, discretine (3), dehydrodiscretine (4), pseudocolumbamine (5), predicentrine (6), and aristolactam AII (7). The structures were established on the basis of spectroscopic data, including mass spectrometry and 2D-NMR. Compound 1 was cytotoxic against KB cells (IC(50) 2.4 microM), while 2, 3, and 4 inhibited Plasmodium falciparum (IC(50) of 4.2, 1.6, and 0.9 microM, respectively).
Document type :
Journal articles
Complete list of metadatas

https://hal.archives-ouvertes.fr/hal-00354186
Contributor : Jocelyne Brunet <>
Submitted on : Monday, January 19, 2009 - 11:10:01 AM
Last modification on : Friday, July 3, 2020 - 4:48:22 PM

Links full text

Identifiers

Collections

Citation

Ngoc Tuan Nguyen, van Cuong Pham, Marc Litaudon, Françoise Guéritte, Philippe Grellier, et al.. Antiplasmodial alkaloids from Desmos rostrata.. Journal of Natural Products, American Chemical Society, 2008, 71 (12), pp.2057-9. ⟨10.1021/np8004437⟩. ⟨hal-00354186⟩

Share

Metrics

Record views

1039