Antiplasmodial alkaloids from Desmos rostrata

Ngoc Tuan Nguyen (1, 2, 3) , van Cuong Pham (4, 5) , Marc Litaudon (6) , Françoise Guéritte (4, 6) , Philippe Grellier (7) , van Tuyen Nguyen (6, 8, 9) , van Hung Nguyen (6, 8, 9)

1 MMC - MicroMachines Centre
2 IBCP - Institut de biologie et chimie des protéines [Lyon]
3 G2ELab - Laboratoire de Génie Electrique de Grenoble
4 Laboratoire de chimie et biochimie des substances naturelles
5 VTGeo - Institute of Geomatic and Remote Sensing
6 ICSN - Institut de Chimie des Substances Naturelles
7 MCAM - Molécules de Communication et Adaptation des Micro-Organismes
8 NISF - National Institute of Soils and Fertilizers
9 E-MOTION - Geometry and Probability for Motion and Action

Two new alkaloids, desmorostratine (1) and discretine N-oxide (2), were isolated from the stem bark of Desmos rostrata, together with five known alkaloids, discretine (3), dehydrodiscretine (4), pseudocolumbamine (5), predicentrine (6), and aristolactam AII (7). The structures were established on the basis of spectroscopic data, including mass spectrometry and 2D-NMR. Compound 1 was cytotoxic against KB cells (IC(50) 2.4 microM), while 2, 3, and 4 inhibited Plasmodium falciparum (IC(50) of 4.2, 1.6, and 0.9 microM, respectively).

Domaines: Biologie cellulaire

Ngoc Tuan Nguyen, van Cuong Pham, Marc Litaudon, Françoise Guéritte, Philippe Grellier, et al.. Antiplasmodial alkaloids from Desmos rostrata. Journal of Natural Products, 2008, 71 (12), pp.2057-9. ⟨10.1021/np8004437⟩. ⟨hal-00354186⟩