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Antiplasmodial alkaloids from Desmos rostrata.

Abstract : Two new alkaloids, desmorostratine (1) and discretine N-oxide (2), were isolated from the stem bark of Desmos rostrata, together with five known alkaloids, discretine (3), dehydrodiscretine (4), pseudocolumbamine (5), predicentrine (6), and aristolactam AII (7). The structures were established on the basis of spectroscopic data, including mass spectrometry and 2D-NMR. Compound 1 was cytotoxic against KB cells (IC(50) 2.4 microM), while 2, 3, and 4 inhibited Plasmodium falciparum (IC(50) of 4.2, 1.6, and 0.9 microM, respectively).
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Submitted on : Monday, January 19, 2009 - 11:10:01 AM
Last modification on : Wednesday, July 6, 2022 - 4:16:22 AM

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Ngoc Tuan Nguyen, van Cuong Pham, Marc Litaudon, Françoise Guéritte, Philippe Grellier, et al.. Antiplasmodial alkaloids from Desmos rostrata.. Journal of Natural Products, American Chemical Society, 2008, 71 (12), pp.2057-9. ⟨10.1021/np8004437⟩. ⟨hal-00354186⟩



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