Antiplasmodial alkaloids from Desmos rostrata.

Abstract : Two new alkaloids, desmorostratine (1) and discretine N-oxide (2), were isolated from the stem bark of Desmos rostrata, together with five known alkaloids, discretine (3), dehydrodiscretine (4), pseudocolumbamine (5), predicentrine (6), and aristolactam AII (7). The structures were established on the basis of spectroscopic data, including mass spectrometry and 2D-NMR. Compound 1 was cytotoxic against KB cells (IC(50) 2.4 microM), while 2, 3, and 4 inhibited Plasmodium falciparum (IC(50) of 4.2, 1.6, and 0.9 microM, respectively).
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Article dans une revue
Journal of Natural Products (Lloydia), 2008, 71 (12), pp.2057-9. 〈10.1021/np8004437〉
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https://hal.archives-ouvertes.fr/hal-00354186
Contributeur : Jocelyne Brunet <>
Soumis le : lundi 19 janvier 2009 - 11:10:01
Dernière modification le : jeudi 7 février 2019 - 17:21:47

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Ngoc Tuan Nguyen, Van Cuong Pham, Marc Litaudon, Françoise Guéritte, Philippe Grellier, et al.. Antiplasmodial alkaloids from Desmos rostrata.. Journal of Natural Products (Lloydia), 2008, 71 (12), pp.2057-9. 〈10.1021/np8004437〉. 〈hal-00354186〉

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