Noninvasive temperature imaging using diffusion MRI.

José Delannoy (1) , C. N. Chen (1, 2, 3) , R. Turner (1) , R. L. Levin (4) , D. Le Bihan (1, 5, 6)

1 Department of Health and Human Services
2 Dept of Electronics & Telecommunications
3 IIS Sinica - Institute of Information Science
4 Department of Biomedical Engineering and Instrumentation program
5 NIH - National Institutes of Health [Bethesda, MD, USA]
6 NEUROSPIN - Service NEUROSPIN

Efficacy and safety considerations for cancer therapy with hyperthermia require accurate temperature measurements throughout the heated volume. We report the use of molecular diffusion, whose temperature dependence is well known. A dedicated hyperthermia applicator was built, combining a MRI gradient coil and a rf coil. Diffusion and derived temperature images were obtained with a 1 x 2 mm pixel size on a polyacrylamide gel phantom using a clinical 1.5-T whole body MRI system. Temperatures determined from these images using 1 cm2 regions of interest were found to be within 0.2 degrees C of those recorded from the thermocouples and fiber-optic probes placed inside the gel.

Domaines: Imagerie; Milieux et Changements globaux

José Delannoy, C. N. Chen, R. Turner, R. L. Levin, D. Le Bihan. Noninvasive temperature imaging using diffusion MRI.. Magnetic Resonance in Medicine, 1991, 19 (2), pp.333-9. ⟨hal-00350070⟩