Detection of fMRI activation using cortical surface mapping.

A. Andrade , F. Kherif , J. F. Mangin (1, 2, 3) , K. J. Worsley (4) , A. L. Paradis (5, 6) , O. Simon (7, 8) , Stanislas Dehaene (2, 9) , D. Le Bihan (2, 10, 11) , J. B. Poline (2, 10)

1 LNAO - Laboratoire de Neuroimagerie Assistée par Ordinateur
2 SHFJ - Service Hospitalier Frédéric Joliot
3 Center for Neuroscience and Behavioral Medicine
4 Montreal Neurological Institute and Hospital
5 LPPA - Laboratoire de Physiologie de la Perception et de l'Action
6 UQAM - Université du Québec à Montréal = University of Québec in Montréal
7 Department of Neurology
8 CHU - Hôpital Pasteur [Nice]
9 LCogn - Neuroimagerie cognitive
10 NEUROSPIN - Service NEUROSPIN
11 IFR 49 - IFR de Neuroimagerie Fonctionnelle

A methodology for fMRI data analysis confined to the cortex, Cortical Surface Mapping (CSM), is presented. CSM retains the flexibility of the General Linear Model based estimation, but the procedures involved are adapted to operate on the cortical surface, while avoiding to resort to explicit flattening. The methodology is tested by means of simulations and application to a real fMRI protocol. The results are compared with those obtained with a standard, volume-oriented approach (SPM), and it is shown that CSM leads to local differences in sensitivity, with generally higher sensitivity for CSM in two of the three subjects studied. The discussion provided is focused on the benefits of the introduction of anatomical information in fMRI data analysis, and the relevance of CSM as a step toward this goal.

Domaines: Imagerie

A. Andrade, F. Kherif, J. F. Mangin, K. J. Worsley, A. L. Paradis, et al.. Detection of fMRI activation using cortical surface mapping.. Human Brain Mapping, 2001, 12 (2), pp.79-93. ⟨hal-00349824⟩