Skip to Main content Skip to Navigation
Journal articles

Functional and structural alterations of the intraparietal sulcus in a developmental dyscalculia of genetic origin.

Abstract : Cognitive theories of numerical representation suggest that understanding of numerical quantities is driven by a magnitude representation associated with the intraparietal sulcus and possibly under genetic control. The aim of this study was to investigate, using fMRI and structural imaging, the interaction between the abnormal development of numerical representation in an X-linked condition, Turner syndrome (TS), and the development of the intraparietal sulcus. fMRI during exact and approximate calculation in TS showed an abnormal modulation of intraparietal activations as a function of number size. Morphological analysis revealed an abnormal length, depth, and sulcal geometry of the right intraparietal sulcus, suggesting an important disorganization of this region in TS. Thus, a genetic form of developmental dyscalculia can be related to both functional and structural anomalies of the right intraparietal sulcus, suggesting a crucial role of this region in the development of arithmetic abilities.
Document type :
Journal articles
Complete list of metadata

https://hal.archives-ouvertes.fr/hal-00349694
Contributor : Denis Le Bihan <>
Submitted on : Saturday, January 3, 2009 - 5:16:22 PM
Last modification on : Monday, July 12, 2021 - 1:24:02 PM

Links full text

Identifiers

Citation

Nicolas Molko, Arnaud Cachia, Denis Rivière, Jean François Mangin, Marie Bruandet, et al.. Functional and structural alterations of the intraparietal sulcus in a developmental dyscalculia of genetic origin.. Neuron, Elsevier, 2003, 40 (4), pp.847-58. ⟨10.1007/s00106-008-1787-x⟩. ⟨hal-00349694⟩

Share

Metrics

Record views

1076