Regulatory function of the P295-T311 motif of the estrogen receptor alpha - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses?

Abstract : The way in which estrogen receptor alpha (ERalpha) mediates gene transcription and hormone-dependent cancer cell proliferation is now being largely reconsidered in view of several recent discoveries. ERalpha-mediated transcription appears to be a cyclic and transient process where the proteasome - and thus receptor degradation - plays a pivotal role. In view of our recent investigations, which demonstrate the estrogenic activity of a synthetic peptide corresponding to a regulatory motif of the receptor (ERalpha17p), we propose that ERalpha proteasomal degradation could induce the emergence of regulatory peptide(s). The latter would function as a signal and contribute to the ERalpha activation process, amplifying the initial hormonal stimulation and giving rise to sustained estrogenic response.
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Submitted on : Wednesday, December 17, 2008 - 4:52:23 PM
Last modification on : Thursday, February 21, 2019 - 10:33:54 AM

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Dominique Gallo, Iman Haddad, Guy Laurent, Joelle Vinh, Françoise Jacquemotte, et al.. Regulatory function of the P295-T311 motif of the estrogen receptor alpha - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses?. Nucl Recept Signal, 2008, 6, pp.e007. ⟨10.1621/nrs.06007⟩. ⟨hal-00348100⟩

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