Regulatory function of the P295-T311 motif of the estrogen receptor alpha - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses?

Abstract : The way in which estrogen receptor alpha (ERalpha) mediates gene transcription and hormone-dependent cancer cell proliferation is now being largely reconsidered in view of several recent discoveries. ERalpha-mediated transcription appears to be a cyclic and transient process where the proteasome - and thus receptor degradation - plays a pivotal role. In view of our recent investigations, which demonstrate the estrogenic activity of a synthetic peptide corresponding to a regulatory motif of the receptor (ERalpha17p), we propose that ERalpha proteasomal degradation could induce the emergence of regulatory peptide(s). The latter would function as a signal and contribute to the ERalpha activation process, amplifying the initial hormonal stimulation and giving rise to sustained estrogenic response.
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Nucl Recept Signal, 2008, 6, pp.e007. 〈10.1621/nrs.06007〉
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https://hal.archives-ouvertes.fr/hal-00348100
Contributeur : Joëlle Vinh <>
Soumis le : mercredi 17 décembre 2008 - 16:52:23
Dernière modification le : mercredi 28 novembre 2018 - 14:08:03

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Dominique Gallo, Iman Haddad, Guy Laurent, Joelle Vinh, Françoise Jacquemotte, et al.. Regulatory function of the P295-T311 motif of the estrogen receptor alpha - does proteasomal degradation of the receptor induce emergence of peptides implicated in estrogenic responses?. Nucl Recept Signal, 2008, 6, pp.e007. 〈10.1621/nrs.06007〉. 〈hal-00348100〉

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