D. Barila and G. Superti-furga, An intramolecular SH3-domain interaction regulates c-Abl activity, Nature Genetics, vol.16, issue.3, pp.280-282, 1998.
DOI : 10.1016/0925-4439(93)90100-F

J. Barros and C. Marshall, Activation of either ERK1/2 or ERK5 MAP kinase pathways can lead to disruption of the actin cytoskeleton, Journal of Cell Science, vol.118, issue.8, pp.1663-71, 2005.
DOI : 10.1242/jcs.02308

T. Boggon and M. Eck, Structure and regulation of Src family kinases, Oncogene, vol.23, issue.48, pp.7918-7945, 2004.
DOI : 10.1038/sj.onc.1208081

/. Rac, . Jnk, and . Rac, Nox pathway for DNA synthesis and c-myc expression induced by growth factors, J. Cell Science, vol.118, pp.3717-3726

S. Boyle, G. Michaud, B. Schweitzer, P. Predki, and A. Koleske, A Critical Role for Cortactin Phosphorylation by Abl-Family Kinases in PDGF-Induced Dorsal-Wave Formation, Current Biology, vol.17, issue.5, 2007.
DOI : 10.1016/j.cub.2007.01.057

B. Brasher, V. Etten, and R. , c-Abl Has High Intrinsic Tyrosine Kinase Activity That Is Stimulated by Mutation of the Src Homology 3 Domain and by Autophosphorylation at Two Distinct Regulatory Tyrosines, Journal of Biological Chemistry, vol.275, issue.45, pp.35631-35638, 2000.
DOI : 10.1074/jbc.M005401200

F. Brembeck, M. Rosario, and W. Birchmeier, Balancing cell adhesion and Wnt signaling, the key role of ??-catenin, Current Opinion in Genetics & Development, vol.16, issue.1, pp.51-60, 2006.
DOI : 10.1016/j.gde.2005.12.007

P. Bromann, H. Korkaya, and S. Courtneidge, The interplay between Src family kinases and receptor tyrosine kinases, Oncogene, vol.23, issue.48, pp.7957-68, 2004.
DOI : 10.1038/sj.onc.1208079

R. Buccione, J. Orth, and M. Mcniven, Foot and mouth: podosomes, invadopodia and circular dorsal ruffles, Nature Reviews Molecular Cell Biology, vol.298, issue.8, pp.647-57, 2004.
DOI : 10.1073/pnas.070552297

E. Burton, R. Plattner, and A. Pendergast, Abl tyrosine kinases are required for infection by Shigella flexneri, The EMBO Journal, vol.22, issue.20, pp.5471-5480, 2003.
DOI : 10.1093/emboj/cdg512

M. Buschbeck, S. Hofbauer, D. Croce, L. Keri, G. Ullrich et al., Abl-kinase-sensitive levels of ERK5 and its intrinsic basal activity contribute to leukaemia cell survival, EMBO reports, vol.62, issue.1, pp.63-72, 2005.
DOI : 10.1067/msy.2002.125389

W. Chen, H. Kung, W. Yang, and L. W. , Comparative tyrosine-kinase profiles in colorectal cancers: Enhanced arg expression in carcinoma as compared with adenoma and normal mucosa, International Journal of Cancer, vol.272, issue.5, pp.579-84, 1999.
DOI : 10.1002/(SICI)1097-0215(19991126)83:5<579::AID-IJC1>3.0.CO;2-R

M. Chiariello, M. Marinissen, and J. Gutkind, Regulation of c-myc expression by PDGF through Rho GTPases, Nature Cell Biology, vol.3, issue.6, pp.580-586, 2001.
DOI : 10.1038/35078555

C. Coyne and J. Bergelson, Virus-Induced Abl and Fyn Kinase Signals Permit Coxsackievirus Entry through Epithelial Tight Junctions, Cell, vol.124, issue.1, pp.119-150, 2006.
DOI : 10.1016/j.cell.2005.10.035

Z. Dai and A. Pendergast, Abi-2, a novel SH3-containing protein interacts with the, 1995.

K. Dorey, J. Engen, J. Kretzschmar, M. Wilm, G. Neubard et al., Phosphorylation and structure-based functional studies reveal a positive and a negative role for the activation loop of the c-Abl tyrosine kinase, Oncogene, vol.20, issue.56, pp.8075-8084, 2001.
DOI : 10.1038/sj.onc.1205017

P. Dowrick, P. Kenworthy, B. Mccann, and R. Warn, Circular ruffle formation and closure lead to macropinocytosis in hepatocyte growth factor/scatter factor-treated cells, Eur J Cell Biol, vol.61, pp.44-53, 1993.

. Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basal-type/"triple-negative" breast cancer cell lines growing in vitro, Breast Cancer Res Treat, vol.105, pp.319-345

*. Furstoss, O. Dorey, K. Simon, V. Barilla, D. Superti-furga et al., c-Abl is an effector of Src for growth factor-induced c-myc expression and DNA synthesis, The EMBO Journal, vol.21, issue.4, pp.514-524, 2002.
DOI : 10.1093/emboj/21.4.514

K. Raine, D. Richardson, R. Shepherd, A. Small, C. Tofts et al., Patterns of somatic mutation in human cancer genomes, Nature, vol.446, pp.153-161, 2007.

G. Furga, A myristoyl/phosphotyrosine switch regulates c-Abl, Cell, vol.112, pp.845-57, 2003.

O. Hantschel and G. Superti-furga, Regulation of the c-Abl and Bcr???Abl Tyrosine Kinases, Nature Reviews Molecular Cell Biology, vol.5, issue.1, pp.33-44, 2004.
DOI : 10.1038/nrm1280

C. Iavarone, M. Acunzo, F. Carlomagno, A. Catania, R. Melillo et al., Activation of the Erk8 Mitogen-activated Protein (MAP) Kinase by RET/PTC3, a Constitutively Active Form of the RET Proto-oncogene, Journal of Biological Chemistry, vol.281, issue.15, pp.10567-76, 2006.
DOI : 10.1074/jbc.M513397200

H. Jin and J. Wang, Abl Tyrosine Kinase Promotes Dorsal Ruffles but Restrains Lamellipodia Extension during Cell Spreading on Fibronectin, Molecular Biology of the Cell, vol.18, issue.10, pp.4143-54, 2007.
DOI : 10.1091/mbc.E07-01-0085

R. Jones, A. Gordus, J. Krall, and G. Macbeath, A quantitative protein interaction network for the ErbB receptors using protein microarrays, Nature, vol.28, issue.7073, pp.168-74, 2006.
DOI : 10.1038/nature04177

J. Jung, A. Pendergast, P. Zipfel, and J. Traugh, Phosphorylation of c-Abl by, 2008.

K. Kain, S. Gooch, and R. Klemke, Cytoplasmic c-Abl provides a molecular ???Rheostat??? controlling carcinoma cell survival and invasion, Oncogene, vol.22, issue.38, pp.6071-80, 2003.
DOI : 10.1038/sj.onc.1206930

K. Kain and R. Klemke, Inhibition of Cell Migration by Abl Family Tyrosine Kinases through Uncoupling of Crk-CAS Complexes, Journal of Biological Chemistry, vol.276, issue.19, pp.16185-92, 2001.
DOI : 10.1074/jbc.M100095200

Y. Kato, V. Kravchenko, R. Tapping, J. Han, R. Ulevitch et al., BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C, The EMBO Journal, vol.16, issue.23, pp.7054-66, 1997.
DOI : 10.1093/emboj/16.23.7054

D. Krause, V. Etten, and R. , Tyrosine Kinases as Targets for Cancer Therapy, New England Journal of Medicine, vol.353, issue.2, pp.172-87, 2005.
DOI : 10.1056/NEJMra044389

E. Krueger, J. Orth, H. Cao, and M. Mcniven, A dynamin-cortactin-Arp2, 2003.

J. Lewis, R. Baskaran, S. Taagepera, M. Schwartz, and J. Wang, Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic-nuclear transport, Proceedings of the National Academy of Sciences, vol.93, issue.26, pp.15174-15183, 1996.
DOI : 10.1073/pnas.93.26.15174

J. Wityak and R. Borzilleri, Discovery of N-(2-chloro-6-methyl-phenyl)-2-(6-(4-(2- hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS- 354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays, J, 2004.

G. Manning, D. Whyte, R. Martinez, T. Hunter, and S. Sudarsanam, The Protein Kinase Complement of the Human Genome, Science, vol.298, issue.5600, pp.1912-1946, 2002.
DOI : 10.1126/science.1075762

T. Matsuguchi, R. Inhorn, N. Carlesso, G. Xu, B. Druker et al., Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABL, Embo J, vol.14, pp.257-65, 1995.

R. Mulloy, S. Salinas, A. Philips, and R. Hipskind, Activation of cyclin D1 expression by the ERK5 cascade, Oncogene, vol.22, issue.35, pp.5387-98, 2003.
DOI : 10.1038/sj.onc.1206839

G. Superti-furga and J. Kuriyan, Structural basis for the autoinhibition of c-Abl tyrosine kinase, Cell, vol.112, pp.859-71, 2003.

N. Noren, G. Foos, C. Hauser, and E. Pasquale, The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl???Crk pathway, Nature Cell Biology, vol.2, issue.8, pp.815-840, 2006.
DOI : 10.1038/ncb1438

A. Olivera, L. Edsall, S. Poulton, A. Kazlauskas, and S. Spiegel, Platelet-derived growth factor-induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCgamma, Faseb J, vol.13, pp.1593-600, 1999.

J. Orth, E. Krueger, S. Weller, and M. Mcniven, A Novel Endocytic Mechanism of Epidermal Growth Factor Receptor Sequestration and Internalization, Cancer Research, vol.66, issue.7, pp.3603-3613, 2006.
DOI : 10.1158/0008-5472.CAN-05-2916

E. Pasquale, Erratum: Eph receptor signalling casts a wide net on cell behaviour, Nature Reviews Molecular Cell Biology, vol.6, issue.7, pp.462-75, 2005.
DOI : 10.1038/nrm1662

A. Pendergast, The Abl family kinases: Mechanisms of regulation and signaling, Adv Cancer Res, vol.85, pp.51-100, 2002.
DOI : 10.1016/S0065-230X(02)85003-5

A. Pendergast, A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1, Nat Cell Biol, vol.5, pp.309-328, 2003.

*. Plattner, R. Kadlec, L. Demali, K. Kazlauskas, A. Pendergast et al., c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF, Genes & Development, vol.13, issue.18, pp.2400-2411, 1999.
DOI : 10.1101/gad.13.18.2400

R. Plattner, A. Koleske, A. Kazlauskas, and A. Pendergast, Bidirectional Signaling Links the Abelson Kinases to the Platelet-Derived Growth Factor Receptor, Molecular and Cellular Biology, vol.24, issue.6, pp.2573-83, 2004.
DOI : 10.1128/MCB.24.6.2573-2583.2004

*. Pluk, H. Dorey, K. Superti-furga, and G. , Autoinhibition of c-Abl, Cell, vol.108, issue.2, 2002.
DOI : 10.1016/S0092-8674(02)00623-2

A. Podtcheko, A. Ohtsuru, S. Tsuda, H. Namba, V. Saenko et al., The Selective Tyrosine Kinase Inhibitor, STI571, Inhibits Growth of Anaplastic Thyroid Cancer Cells, The Journal of Clinical Endocrinology & Metabolism, vol.88, issue.4, pp.1889-96, 2003.
DOI : 10.1210/jc.2002-021230

S. Polo, S. Pece, D. Fiore, and P. , Endocytosis and cancer, Current Opinion in Cell Biology, vol.16, issue.2, pp.156-61, 2004.
DOI : 10.1016/j.ceb.2004.02.003

M. Renshaw, E. Lea-chou, and J. Wang, Rac is required for v-Abl tyrosine kinase to activate mitogenesis, Current Biology, vol.6, issue.1, pp.76-83, 1996.
DOI : 10.1016/S0960-9822(02)00424-4

M. Resh, Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1451, issue.1, pp.1-16, 1999.
DOI : 10.1016/S0167-4889(99)00075-0

J. Rhee, N. Mahfooz, C. Arregui, J. Lilien, J. Balsamo et al., Activation of the repulsive receptor Roundabout inhibits N-cadherin-mediated cell adhesion, Nature Cell Biology, vol.4, issue.10, pp.798-805, 2002.
DOI : 10.1038/ncb858

Y. Hu, Z. Tan, M. Stokes, L. Sullivan, J. Mitchell et al., Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer, Cell, vol.131, pp.1190-203, 2007.

S. Roche, S. Courtneidge, K. H. Peters, and . Vousden, Oncogenic cytoplasmic tyrosine kinases, pp.87-119, 1997.

C. Sawyers, J. Mclaughlin, A. Goga, M. Havlik, and O. Witte, The nuclear tyrosine kinase c-abl negatively regulates cell growth, Cell, vol.77, issue.1, pp.121-152, 1994.
DOI : 10.1016/0092-8674(94)90240-2

B. Schmierer and C. Hill, TGF?????SMAD signal transduction: molecular specificity and functional flexibility, Nature Reviews Molecular Cell Biology, vol.31, issue.12, pp.970-82, 2007.
DOI : 10.1038/nrm2297

P. Schwartzberg, A. Stall, J. Hardin, K. Bowdish, T. Humaran et al., Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations, Cell, vol.65, issue.7, pp.1165-75, 1991.
DOI : 10.1016/0092-8674(91)90012-N

Y. Shi, K. Alin, and S. Goff, Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity., Genes & Development, vol.9, issue.21, pp.2583-97, 1995.
DOI : 10.1101/gad.9.21.2583

P. Sini, A. Cannas, A. Koleske, D. Fiore, P. Scita et al., Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation, Nature Cell Biology, vol.6, issue.3, pp.268-74, 2004.
DOI : 10.1038/ncb1096

*. Sirvent, A. Boureux, A. Simon, V. Leroy, C. Roche et al., The tyrosine kinase Abl is required for Src-transforming activity in mouse fibroblasts and human breast cancer cells, Oncogene, vol.274, issue.52, 2007.
DOI : 10.1038/sj.onc.1210543

URL : https://hal.archives-ouvertes.fr/hal-00189107

K. Sossey-alaoui, X. Li, and J. Cowell, c-Abl-mediated Phosphorylation of WAVE3 Is Required for Lamellipodia Formation and Cell Migration, Journal of Biological Chemistry, vol.282, issue.36, pp.26257-65, 2007.
DOI : 10.1074/jbc.M701484200

*. Srinivasan, D. Plattner, and R. , Activation of Abl Tyrosine Kinases Promotes Invasion of Aggressive Breast Cancer Cells, Cancer Research, vol.66, issue.11, pp.5648-55, 2006.
DOI : 10.1158/0008-5472.CAN-06-0734

D. Srinivasan, J. Sims, and R. Plattner, Aggressive breast cancer cells are dependent on activated Abl kinases for proliferation, anchorage-independent growth and survival, Oncogene, vol.8, issue.8, 2007.
DOI : 10.1038/sj.bjc.6690250

M. Stanglmaier, M. Warmuth, I. Kleinlein, S. Reis, and M. Hallek, The interaction of the Bcr-Abl tyrosine kinase with the Src kinase Hck is mediated by multiple binding domains, Leukemia, vol.17, issue.2, pp.283-292, 2003.
DOI : 10.1038/sj.leu.2402778

M. Wilkes and E. Leof, Transforming Growth Factor beta Activation of c-Abl Is Independent of Receptor Internalization and Regulated by Phosphatidylinositol 3-Kinase and PAK2 in Mesenchymal Cultures, Journal of Biological Chemistry, vol.281, issue.38, pp.27846-54, 2006.
DOI : 10.1074/jbc.M603721200

R. Wierenga, The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions, J Mol Biol, vol.274, pp.757-75, 1997.

P. Woodring, T. Hunter, and J. Wang, Inhibition of c-Abl Tyrosine Kinase Activity by Filamentous Actin, Journal of Biological Chemistry, vol.276, issue.29, pp.27104-27114, 2001.
DOI : 10.1074/jbc.M100559200

P. Woodring, T. Hunter, and J. Wang, Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases, Journal of Cell Science, vol.116, issue.13, pp.2613-2639, 2003.
DOI : 10.1242/jcs.00622

W. Xu, S. Harrison, and M. Eck, Three-dimensional structure of the tyrosine kinase c-Src, Nature, vol.385, issue.6617, 1997.
DOI : 10.1038/385595a0

*. Yang, L. Lin, C. Liu, and Z. , P68 RNA Helicase Mediates PDGF-Induced Epithelial Mesenchymal Transition by Displacing Axin from ??-Catenin, Cell, vol.127, issue.1, pp.139-55, 2006.
DOI : 10.1016/j.cell.2006.08.036

P. Zipfel, W. Zhang, M. Quiroz, and A. Pendergast, Requirement for Abl Kinases in T Cell Receptor Signaling, Current Biology, vol.14, issue.14, pp.1222-1253, 2004.
DOI : 10.1016/j.cub.2004.07.021

S. Zrihan-licht, A. S. Jiang, S. Fu, Y. , and A. H. , Coupling of RAFTK/Pyk2 kinase with c-Abl and their role in the migration of breast cancer cells, International Journal of Oncology, vol.24, pp.153-162, 2004.
DOI : 10.3892/ijo.24.1.153