Acylphenols from Myristica crassa as new acetylcholinesterase inhibitors.

Alessandra Maia (1) , Isabelle Schmitz-Afonso (1) , Marie-Thérèse Martin (1) , Khalijah Awang , Olivier Laprévote (1) , Françoise Guéritte (1) , Marc Litaudon (1)

1 ICSN - Institut de Chimie des Substances Naturelles

A significant acetylcholinesterase inhibitory activity was observed for the ethyl acetate and methanol extracts from the leaves and the fruits of MYRISTICA CRASSA. Three new dimeric acylphenols, giganteone C ( 5), maingayones B and C ( 6 and 7) were isolated together with the known malabaricones B and C ( 2 and 3) and giganteone A ( 4). Compounds 2 and 3 possess significant inhibitory activity on acetylcholinesterase. LC/MS study was particularly useful to discriminate structures of compounds 6 and 7.

Domaines: Biologie cellulaire

Alessandra Maia, Isabelle Schmitz-Afonso, Marie-Thérèse Martin, Khalijah Awang, Olivier Laprévote, et al.. Acylphenols from Myristica crassa as new acetylcholinesterase inhibitors.. Planta Medica, 2008, 74 (12), pp.1457-62. ⟨10.1055/s-2008-1081336⟩. ⟨hal-00345171⟩