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The Redox Protein Construction Kit; Pre-LUCA Evolution of Energy Conserving Enzymes

Abstract : Genome analyses and the resolution of three-dimensional structures have provided evidence in recent years for hitherto unexpected family relationships between redox proteins of very diverse enzymes involved in bioenergetic electron transport. Many of these enzymes appear in fact to be constructed from only a limited set of building blocks. Phylogenetic analysis of selected units from this "redox enzyme construction kit" indicates an origin for several prominent bioenergetic enzymes that is very early, lying before the divergence of Bacteria and Archaea. Possible scenarios for the early evolution of selected complexes are proposed based on the obtained tree topologies.
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Frauke Baymann, Evelyne Lebrun, Myriam Brugna, Barbara Schoepp-Cothenet, Marie-Thérèse Giudici-Orticoni, et al.. The Redox Protein Construction Kit; Pre-LUCA Evolution of Energy Conserving Enzymes. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences (1934–1990), Royal Society, The, 2003, 358, pp.267-274. ⟨10.1098/rstb.2002.1184⟩. ⟨hal-00343715⟩

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