Binding of aminoglycoside antibiotics to the duplex form of the HIV-1 genomic RNA dimerization initiation site.

Séverine Freisz (1) , Kathrin Lang (2) , Ronald Micura (2) , Philippe Dumas (1) , Eric Ennifar (1)

1 ARN - Architecture et réactivité de l'ARN
2 Institute of Organic Chemistry, Center for Molecular Biosciences

Mots clés: antibiotics; drug design; HIV; molecular recognition; RNA structures

Domaines: Biochimie, Biologie Moléculaire; Biologie cellulaire

Séverine Freisz, Kathrin Lang, Ronald Micura, Philippe Dumas, Eric Ennifar. Binding of aminoglycoside antibiotics to the duplex form of the HIV-1 genomic RNA dimerization initiation site.. Angewandte Chemie International Edition, 2008, 47 (22), pp.4110-3. ⟨10.1002/anie.200800726⟩. ⟨hal-00341699⟩