Inexpensive anti-cysticercosis vaccine: S3Pvac expressed in heat inactivated M13 filamentous phage proves effective against naturally acquired Taenia solium porcine cysticercosis.

Julio Morales , José Juan Martínez , Karen Manoutcharian , Marisela Hernández , Agnès Fleury (1) , Goar Gevorkian , Gonzalo Acero , Abel Blancas , Andrea Toledo , Jacquelynne Cervantes , Victor Maza , Fabrice Quet (1, 2) , Henri Bonnabau (2) , Aline S de Aluja , Gladis Fragoso , Carlos Larralde , Edda Sciutto

1 NETEC - Neuroépidémiologie Tropicale et Comparée
2 SIME - Service de l'Information Médicale et de l'Évaluation [CHU Limoges]

In search of reducing vaccine production costs', a recombinant M13 phage version of the anti-cysticercosis tripeptide vaccine (S3Pvac) was developed. The efficacy of S3Pvac-Phage vs. placebo was evaluated in a randomized trial that included 1,047 rural pigs in 16 villages of Central Mexico. Three to five months after vaccination 530 pigs were examined by tongue inspection. At 5-27 months of age, 331 pigs (197 vaccinated/134 controls) were inspected at necropsy. Vaccination reduced 70% the frequency of tongue cysticercosis and, based on necropsy, 54% of muscle-cysticercosis and by 87% the number of cysticerci.

Domaines: Parasitologie; Santé publique et épidémiologie

Julio Morales, José Juan Martínez, Karen Manoutcharian, Marisela Hernández, Agnès Fleury, et al.. Inexpensive anti-cysticercosis vaccine: S3Pvac expressed in heat inactivated M13 filamentous phage proves effective against naturally acquired Taenia solium porcine cysticercosis.. Vaccine, 2008, 26 (23), pp.2899-905. ⟨10.1016/j.vaccine.2008.03.042⟩. ⟨hal-00338040⟩