E. Hawk and B. Levin, Colorectal Cancer Prevention, Journal of Clinical Oncology, vol.23, issue.2, pp.378-91, 2005.
DOI : 10.1200/JCO.2005.08.097

H. Witschi, Lung tumor development in mice exposed to tobacco smoke and fed beta-carotene diets, Toxicological Sciences, vol.69, issue.1, pp.23-29, 2002.

M. Forman, S. Hursting, A. Umar, and J. Barrett, NUTRITION AND CANCER PREVENTION: A Multidisciplinary Perspective on Human Trials, Annual Review of Nutrition, vol.24, issue.1, pp.223-54, 2004.
DOI : 10.1146/annurev.nutr.24.012003.132315

A. Gescher and W. Steward, Relationship between mechanisms, bioavailibility, and preclinical chemopreventive efficacy of resveratrol: a conundrum, Cancer Epidemiol Biomarkers Prev, vol.12, issue.10, pp.953-960, 2003.

K. Kinzler and B. Vogelstein, Lessons from Hereditary Colorectal Cancer, Cell, vol.87, issue.2, pp.159-170, 1996.
DOI : 10.1016/S0092-8674(00)81333-1

B. Vogelstein, D. Lane, and A. Levine, Surfing the p53 network, Nature, vol.408, issue.6810, pp.307-310, 2000.
DOI : 10.1038/35042675

Y. Xing, W. Clements, D. Kimelman, and W. Xu, Crystal structure of a ??-catenin/Axin complex suggests a mechanism for the ??-catenin destruction complex, Genes & Development, vol.17, issue.22, pp.2753-2764, 2003.
DOI : 10.1101/gad.1142603

H. Clevers, Wnt breakers in colon cancer, Cancer Cell, vol.5, issue.1, pp.5-6, 2004.
DOI : 10.1016/S1535-6108(03)00339-8

R. Fodde, J. Kuipers, C. Rosenberg, R. Smits, M. Kielman et al., Mutations in the APC tumour suppressor gene cause chromosomal instability Role of APC and DNA mismatch repair genes in the development of colorectal cancers, Nature Cell Biology Molecular Cancer, vol.32, issue.1141, pp.433-4381, 2001.

D. Chung, A. Rustgi, B. Trinh, T. Long, A. Nickel et al., The hereditary nonpolyposis colorectal cancer syndrome: genetics and clinical implications DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair, Ann Intern Med Molecular and Cellular Biology, vol.13822, issue.139, pp.560-5702906, 2002.

P. Dolara, -dimethylhydrazine-treated rats Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents More frequent beta-catenin gene mutations in adenomas than in aberrant crypt foci or adenocarcinomas in the large intestines of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (phIP)treated rats, Moser AR, Pitot HC, Dove WF. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse, pp.475-480792, 1990.
URL : https://hal.archives-ouvertes.fr/hal-01203972

D. Corpet and F. Pierre, Point: from animal models to prevention of colon cancer. systematic review of chemoprevention in min mice and choice of the model system, Cancer Epidemiology Biomarkers & Prevention, vol.12, issue.5, pp.391-400, 2003.
URL : https://hal.archives-ouvertes.fr/hal-00411768

B. Ahn, H. Ohshima, M. Oshima, J. Dinchuk, S. Kargman et al., Suppression of intestinal polyposis in Apc (Min/+) mice by inhibiting nitric oxide production Suppression of intestinal polyposis in apc(delta 716) knockout mice by inhibition of cyclooxygenase 2 (COX-2), Cancer Research Cell, vol.6187, issue.205, pp.8357-8360803, 1996.

P. Laird, L. Jackson-grusby, A. Fazeli, S. Dickinson, W. Jung et al., Suppression of intestinal neoplasia by DNA hypomethylation, Cell, vol.81, issue.2, pp.197-205, 1995.
DOI : 10.1016/0092-8674(95)90329-1

N. Dewind, M. Dekker, A. Vanrossum, M. Vandervalk, and H. Riele, Mouse models for hereditary nonpolyposis colorectal cancer, Cancer Research, vol.58, issue.2, pp.248-255, 1998.

K. Wei, R. Kucherlapati, W. Edelmann, J. Green, T. Hudson et al., The promise of genetically engineered mice for cancer prevention studies Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers Response of Apc(min) and A33(delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6- phenylimidazo Mutation Research -Fundamental and Molecular Mechanisms of, Mouse models for human DNA mismatch-repair gene defects, pp.346-353184, 2002.

R. Sandler, Calcium supplements for the prevention of colorectal adenomas, New England Journal of Medicine BonithonKopp C, vol.340, issue.28, pp.101-107, 1999.

B. Hofstad, K. Almendingen, M. Vatn, S. Andersen, R. Owen et al., Growth and recurrence of colorectal polyps: a double-blind 3-year intervention with calcium and antioxidants A randomized trial of aspirin to prevent colorectal adenomas, Digestion New England Journal of Medicine, vol.59348, issue.3010, pp.148-156891, 1998.

R. Sandler, S. Halabi, J. Baron, S. Budinger, E. Paskett et al., A Randomized Trial of Aspirin to Prevent Colorectal Adenomas in Patients with Previous Colorectal Cancer, New England Journal of Medicine, vol.348, issue.10, pp.883-890, 2003.
DOI : 10.1056/NEJMoa021633

B. Piednoir, Daily soluble aspirin and prevention of colorectal adenoma recurrence: one-year results of the APACC trial Role of supplemental calcium in the recurrence of colorectal adenomas: a metaanalysis of randomized controlled trials, Gastroenterology Am J Gastroenterol, vol.125100, issue.22, pp.328-336390, 2003.

D. Alberts, M. Martinez, D. Roe, J. Guillenrodriguez, J. Marshall et al., Lack of Effect of a High-Fiber Cereal Supplement on the Recurrence of Colorectal Adenomas, New England Journal of Medicine, vol.342, issue.16, pp.1156-1162, 2000.
DOI : 10.1056/NEJM200004203421602

H. Gratten, A randomized trial of vitamins C and E in the prevention of recurrence of colorectal polyps Toronto-Polyp-Prevention-Group. A randomized trial of a low fat high fibre diet in the recurrence of colorectal polyps, Journal of the National Cancer Institute Cancer Res Journal of Clinical Epidemiology New England Journal of Medicine, vol.874847342, issue.3816, pp.1760-17664701, 1988.

E. Greenberg, J. Baron, T. Tosteson, D. Freeman, G. Beck et al., A Clinical Trial of Antioxidant Vitamins to Prevent Colorectal Adenoma, New England Journal of Medicine, vol.331, issue.3, pp.141-147, 1994.
DOI : 10.1056/NEJM199407213310301

M. Cucherat, J. Boissel, and A. Leizorovicz, EasyMA: a program for the meta-analysis of clinical trials, Computer Methods and Programs in Biomedicine, vol.53, issue.3, pp.187-190, 1997.
DOI : 10.1016/S0169-2607(97)00016-3

P. Craven and F. Derubertis, Effects of aspirin on 1, 2-dimethylhydrazine-induced colonic carcinogenesis, Carcinogenesis, vol.13, issue.4, pp.541-546, 1992.
DOI : 10.1093/carcin/13.4.541

B. Reddy, C. Rao, A. Rivenson, G. Kelloff, A. Davis et al., Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in f344 rats Aspirin reduces the incidence of colonic carcinoma in the dimethylhydrazine rat animal model, Carcinogenesis Australian and New Zealand Journal of Medicine, vol.1424, issue.433, pp.1493-1497301, 1993.

H. Li, H. Schut, P. Conran, P. Kramer, R. Lubet et al., Prevention by aspirin and its combination with alphadifluoromethylornithine of azoxymethane-induced tumors, aberrant crypt foci and prostaglandin e-2 levels in rat colon Barnes CJ, Lee M. Determination of an optimal dosing regimen for aspirin chemoprevention of 1,2-dimethylhydrazine-induced colon tumours in rats The combination of 1alpha,25(OH2)-vitamin D3, calcium and acetylsalicylic acid affects azoxymethane-induced aberrant crypt foci and colorectal tumours in rats The effect of aspirin and high fibre diet on colorectal carcinoma: a comparative experimental study, Carcinogenesis Br J Cancer Cancer Lett Tech Coloproctol, vol.20791868, issue.461 1, pp.425-43019, 1999.

N. Mahmoud, A. Dannenberg, J. Mestre, R. Bilinski, M. Churchill et al., Aspirin prevents tumors in a murine model of familial adenomatous polyposis Chemoprevention of spontaneous intestinal adenomas in the adenomatous polyposis coli min mouse model with aspirin, Surgery Gastroenterology, vol.124114, issue.505, pp.225-31873, 1998.

R. Fodde and J. Burn, Intestinal tumorigenesis in the apc1638n mouse treated with aspirin and resistant starch for up to 5 months, Carcinogenesis, vol.20, issue.5, pp.805-810, 1999.

C. Chiu, M. Mcentee, and J. Whelan, Discordant effect of aspirin and indomethacin on intestinal tumor burden inApcMin/+ mice, Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), vol.62, issue.5, pp.269-75, 2000.
DOI : 10.1054/plef.2000.0154

O. Sansom, L. Stark, M. Dunlop, and A. Clarke, Suppression of intestinal and mammary neoplasia by lifetime administration of aspirin in Apc, Cancer Research, vol.61, pp.27060-7064, 2001.

B. Reuter, X. Zhang, M. Miller, S. Perkins, A. Clarke et al., Therapeutic utility of aspirin in the ApcMin/+ murine model of colon carcinogenesis):19. 55 Age-related difference in susceptibility of Apc(Min/+) mice towards the chemopreventive efficacy of dietary aspirin and curcumin, BMC Cancer Br J Cancer, vol.288, issue.19, pp.1480-1483, 2002.

T. Colacchio and V. Memoli, Chemoprevention of Colorectal Neoplasms, Archives of Surgery, vol.121, issue.12, pp.1421-1425, 1986.
DOI : 10.1001/archsurg.1986.01400120071012

N. Temple, T. Basu, K. Imaida, M. Hirose, S. Yamaguchi et al., Effects of naturally occuring antioxydants on combined DMH and MNU intitated carcinogenesis in F344 male rats Effect of betacarotene , sodium ascorbate and cellulose on 1,2-dimethylhydrazine- induced intestinal carcinogenesis in rats Effect of calcium on azoxymethane induced intestinal tumors in rats The effect of dietary milk and calcium on experimental colorectal carcinogenesis Inhibition of dietary fat-promoted colon carcinogenesis in rats by supplemental calcium or vitamin D3, )):#1332. 61. Nelson RL, pp.1211-1215, 1987.

C. Mcsherry, B. .. Cohen, J. Scholes, M. Wargovich, D. Allnutt et al., Effect of calcium and bile acid feeding on colon tumors in the rat Inhibition of the promotional phase of azoxymethane induced colon carcinogenesis in the F344 rat by calcium lactate : effect of simulationg 2 human nutrient density levels Dietary Calcium and Vitamin-D Modulate 1,2-Dimethylhydrazine-Induced Colonic Carcinogenesis in the Rat, Cancer Research Cancer Letters Cancer Research, vol.495351, issue.6520, pp.6039-604317, 1989.

M. Karkare, T. Clark, H. Glauert, G. Barsoum, H. Thompson et al., Effect of Dietary Calcium on Colon Carcinogenesis Induced by a Single Injection of 1,2- Dimethylhydrazine in Rats Dietary calcium does not reduce experimental colorectal carcinogenesis after small bowel resection despite reducing cellular proliferation Influence of dietary calcium and vitamin-d on colon epithelial cell proliferation and 1,2- dimethylhydrazine-induced colon carcinogenesis in rats fed high fat diets Protective effects of calcium from nonfat dried milk against colon carcinogenesis in rats, Journal of Nutrition Gut J Nutr Nutrition and Cancer Belbraouet S, vol.1213312325, issue.70, pp.568-5771515, 1991.

J. Floquet, Dietary calcium salts as protective agents and laminin P1 as a biochemical marker in chemically induced colon carcinogenesis in rats, Cancer Detect Prev, vol.20, issue.4, pp.294-303, 1996.

D. Quilliot, S. Belbraouet, X. Pelletier, J. Gueant, J. Floquet et al., Influence of a high-calcium carbonate diet on the incidence of experimental colon cancer in rats Calcium inhibits colon carcinogenesis in an experimental model in the rat, Nutrition and Cancer European Journal of Cancer, vol.3434, issue.212, pp.213-2191941, 1998.

R. Adell-carceller, M. Segarra-soria, J. Gibert-jerez, S. Sanchis, J. Lazaro-santander et al., Inhibitory effect of calcium on carcinogenesis at the site of colonic anastomosis, Diseases of the Colon & Rectum, vol.40, issue.11, pp.1376-81505, 1990.
DOI : 10.1007/BF02050826

S. Huerta, R. Irwin, D. Heber, V. Go, F. Moatamed et al., Intestinal polyp formation in the apc(min) mouse effects of levels of dietary calcium and altered vitamin d homeostasis, Digestive Diseases and Sciences, vol.48, issue.5, pp.870-876, 2003.
DOI : 10.1023/A:1023083025595

K. Yang, W. Edelmann, K. Fan, K. Lau, D. Leung et al., Dietary modulation of carcinoma development in a mouse model for human familial adenomatous polyposis Targeted inactivation of p27(kip1) is sufficient for large and small intestinal tumorigenesis in the mouse, which can be augmented by a western-style high-risk diet Targeted inactivation of the p21(WAF1/cip1) gene enhances apc-initiated tumor formation and the tumor-promoting activity of a western-style high-risk diet by altering cell maturation in the intestinal mucosa, Cancer Research Cancer Research Cancer Research, vol.586361, issue.792, pp.5713-57174990, 1998.

T. Barbolt and R. Abraham, Dose-response, sex difference, and the effect of bran in dimethylhydrazine-induced intestinal tumorigenesis in rats The effect of bran on dimethylhydrazine-induced colon carcinogenesis in the rat, Toxicol Appl Pharmacol Proc Soc Exp Biol Med, vol.55157, issue.814, pp.417-22656, 1978.

B. Reddy, H. Mori, M. Nicolais, B. Pence, H. Budding et al., Effect of dietary wheat bran and dehydrated citrus fiber on azoxymethane-induced intestinal carcinogenesis in Fischer 344 rats Jacobs LR. Enhancement of rat colon carcinogenesis by wheat bran consumption during the stage of 1,2-dimethylhydrazine administration Multiple dietary factors in the enhancement of dimethylhydrazine carcinogenesis: Main effect of indole-3-carbinol Interactive effects of dietary wheat bran and lard on Nmethyl-N'-nitro-N-nitrosoguanidine induced colon carcinogenesis in rats, F344 rats Kritchevsky D, Klurfeld DM. Interaction of fiber and energy restriction in experimental colon carcinogenesis, pp.141-146, 1979.

T. Takahashi, M. Satou, N. Watanabe, Y. Sakaitani, A. Takagi et al., Inhibitory effect of microfibril wheat bran on azoxymethane-induced colon carcinogenesis in CF1 mice Wheat aleurone flour increases cecal beta-glucuronidase activity and butyrate concentration and reduces colon adenoma burden in azoxymethane-treated rats Do aberrant crypt foci have predictive value for the occurrence of colorectal tumours? Potential of gene expression profiling in tumours Effect of dietary wheat bran and dehydrated citrus fiber on 3,2'-dimethyl-4-aminobiphenyl-induced intestinal carcinogenesis in F344 rats, 92. Mutanen M, Pajari AM, Oikarinen SI. Beef induces and rye bran prevents the formation of intestinal polyps in apc(min) mice: relation to beta-catenin and PKC isozymes, pp.139-146127, 1981.

J. Menanteau, Short-chain fructo-oligosaccharides reduce the occurrence of colon tumors and develop gut-associated lymphoid tissue in min mice, Cancer Research, vol.57, issue.2, pp.225-228, 1997.

K. Hioki, N. Shivapurkar, H. Oshima, O. Alabaster, M. Oshima et al., Suppression of intestinal polyp development by low-fat and high-fiber diet in Apc(delta716) knockout mice, Carcinogenesis, vol.18, issue.10, pp.1863-1865, 1997.
DOI : 10.1093/carcin/18.10.1863

Z. Yu, M. Xu, G. Santanarios, R. Shen, M. Izquierdopulido et al., A comparison of whole wheat, refined wheat and wheat bran as inhibitors of heterocyclic amines in the Salmonella mutagenicity assay and in the rat colonic aberrant crypt focus assay, Food and Chemical Toxicology, vol.39, issue.7, pp.655-665, 2001.
DOI : 10.1016/S0278-6915(01)00012-6

K. Drankhan, J. Carter, R. Madl, C. Klopfenstein, F. Padula et al., Antitumor activity of wheats with high orthophenolic content 97. Toth B. Effect of Metamucil on tumour formation by 1,2- dimethylhydrazine dihydrochloride in mice A Western-style diet induces benign and malignant neoplasms in the colon of normal C57Bl/6 mice, Nutr Cancer Food Chem Toxicol Carcinogenesis, vol.472222, issue.2711, pp.188-941871, 1984.

W. Bruce, Counterpoint: From animal models to prevention of colon cancer. Criteria for proceeding from preclinical studies and choice of models for prevention studies, Cancer Epidemiol Biomarkers Prev, vol.12, issue.5, pp.401-405, 2003.

D. Corpet and G. Parnaud, Polyethylene-glycol, a potent suppressor of azoxymethane-induced colonic aberrant crypt foci in rats, Carcinogenesis, vol.20, issue.5, pp.915-918, 1999.
DOI : 10.1093/carcin/20.5.915

J. Jankowski, Prevention of colorectal adenomas by polyethylene glycol (PEG): a population-based study of 1165 colonoscopies in France, Proc. AACR, vol.44, pp.174-979, 2003.

F. Pierre, S. Tache, C. Petit, R. Van-der-meer, D. Corpet et al., Meat and cancer: haemoglobin and haemin in a low-calcium diet promote colorectal carcinogenesis at the aberrant crypt stage in rats Colorectal cancer prevention: is an ounce of prevention worth a pound of cure?, Carcinogenesis Semin Oncol, vol.2432, issue.1041, pp.1683-9024, 2003.

P. Harris and L. Ferguson, Dietary fibre -its composition and role in protection against colorectal cancer Bird RP. Observation and quantification of aberrant crypts in murine colon treated with a colon carcinogen: preliminary findings, Mutation Research Cancer Lett, vol.29037, issue.107, pp.97-110147, 1987.

S. Sakamaki, Aberrant crypt foci of the colon as precursors of adenoma and cancer Transcriptional profiles of intestinal tumors in Apc(Min) mice are unique from those of embryonic intestine and identify novel gene targets dysregulated in human colorectal tumors, New England Journal of Medicine Cancer Res, vol.33965, issue.1081, pp.1277-1284166, 1998.