Biophysical cortical column model for optical signal analysis

Sandrine Chemla (1) , Thierry Viéville (2) , Frederic Chavane (2)

1 ODYSSEE - Computer and biological vision
2 CORTEX - Neuromimetic intelligence

We propose a biological cortical column model, at a mesoscopic scale, in order to better understand and interpret biological sources of voltage-sensitive dye imaging signal (VSD signal). This scale corresponds to one pixel of optical imaging: about 50 um. Simulations are with the NEURON software and visualization with the NEUROCONSTRUCT software. This model confirms and quantifies the fact that the optical signal is the result of an average from multiple components but shows surprisingly that inhibitory cells, spiking activity and deep layers likely participate more to the signal than initially though.

Mots clés: Neuronal models; Brain-computer interfaces; Neural Prostheses; Brain Imaging

Domaines: Neurosciences [q-bio.NC]; Neurosciences

Sandrine Chemla, Thierry Viéville, Frederic Chavane. Biophysical cortical column model for optical signal analysis. Deuxième conférence française de Neurosciences Computationnelles, "Neurocomp08", Oct 2008, Marseille, France. ⟨hal-00331587⟩