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Clinical practice of rTMS reveals a functional dissociation between agency and hallucinations in schizophrenia.

Abstract : We report here the case of a hospitalized 11 year-old boy (YP) with a positive diagnosis of 'Childhood Onset Schizophrenia'. YP experienced verbal-auditory hallucinations, a delusion of alien control and hetero-aggressive behaviour. Antipsychotic drugs were unsuccessful and furthermore provoked severe acute dystonia. fMRI-guided rTMS applied over several cortical regions provided the means to reveal for the first time a functional dissociation between auditory-verbal hallucinations and agency. These results demonstrate the efficacy of rTMS for young patients suffering from drug-resistant hallucinations but they furthermore question the physiopathology of the hallucinatory process by suggesting that agency and hallucinations may be sub-served by different neural networks.
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https://hal.archives-ouvertes.fr/hal-00331402
Contributor : Anny Wartel <>
Submitted on : Thursday, October 16, 2008 - 3:37:39 PM
Last modification on : Thursday, November 12, 2020 - 2:52:03 PM

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Renaud Jardri, Yvonne Delevoye-Turrell, Bernard Lucas, Delphine Pins, Virginie Bulot, et al.. Clinical practice of rTMS reveals a functional dissociation between agency and hallucinations in schizophrenia.. Neuropsychologia, Elsevier, 2008, 47 (1), pp.132-138. ⟨10.1016/j.neuropsychologia.2008.08.006⟩. ⟨hal-00331402⟩

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