P. J. -halling, Water activity in biphasic reaction systems, Biocatalysis in organic media, pp.125-132, 1987.

J. M. -cassels and P. J. Halling, Effect of thermodynamic water activity on thermolysin-catalysed peptide synthesis in organic two-phase systems, Enzyme and Microbial Technology, vol.10, issue.8, 1988.
DOI : 10.1016/0141-0229(88)90026-9

M. Goldberg, F. Parvaresh, D. Thomas, and M. D. Legoy, Enzymatic ester synthesis with continuous measurement of water activity, Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, vol.957, issue.3, pp.359-362, 1988.
DOI : 10.1016/0167-4838(88)90226-9

M. -goldberg, D. Thomas, and M. D. Legoy, Water activity as a key parameter of synthesis reactions: The example of lipase in biphasic (liquid/solid) media, Enzyme and Microbial Technology, vol.12, issue.12, pp.976-981, 1990.
DOI : 10.1016/0141-0229(90)90120-F

G. -ljunger, P. Adlercreutz, and B. Mattiasson, Enzymatic synthesis of octyl-??-glucoside in octanol at controlled water activity, Enzyme and Microbial Technology, vol.16, issue.9, pp.751-755, 1994.
DOI : 10.1016/0141-0229(94)90031-0

J. A. -rupley, E. Gratton, and G. Careri, Water and globular proteins, Trends in Biochemical Sciences, vol.8, issue.1, pp.18-22, 1983.
DOI : 10.1016/0968-0004(83)90063-4

R. H. -valivety, P. J. Halling, and A. R. Macrae, Lipases from different sources vary widely in dependence of catalytic activity on water activity, Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, vol.1122, issue.2, pp.143-146, 1992.
DOI : 10.1016/0167-4838(92)90316-6

R. H. -valivety, P. J. Halling, and A. R. Macrae, Reaction rate with suspended lipase catalyst shows similar dependence on water activity in different organic solvents, Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, vol.1118, issue.3, 1992.
DOI : 10.1016/0167-4838(92)90278-L

-. Erp, S. H. Kamenskaya, E. O. Khmelnitsky, and Y. L. , The effect of water content and nature of organic solvent on enzyme activityin low-water media, Eur. J, 1991.

R. H. -valivety, P. J. Halling, and A. R. Macrae, Water as a competitive inhibitor of lipase-catalysed esterification in organic media, Biotechnology Letters, vol.34, issue.11, pp.1133-1138, 1993.
DOI : 10.1007/BF00131203

R. -bovara, G. Carrea, G. Ottolina, and S. Riva, Effects of water activity on Vmax and KM of lipase catalyzed transesterification in organic media, Biotechnology Letters, vol.263, issue.9, pp.937-942, 1993.
DOI : 10.1007/BF00131760

E. Wehtje and P. Adlercreutz, Water activity and substrate concentration effects on lipase activity, Biotechnology and Bioengineering, vol.263, issue.5, pp.798-806, 1997.
DOI : 10.1002/(SICI)1097-0290(19970905)55:5<798::AID-BIT10>3.0.CO;2-8

A. -marty, W. Chulalaksananukul, R. M. Willemot, and J. S. Condoret, Kinetics of lipase-catalyzed esterification in supercritical CO2, Biotechnology and Bioengineering, vol.8, issue.3, pp.273-280, 1992.
DOI : 10.1002/bit.260390304

S. -lamare and M. D. Legoy, Working at controlled water activity in a continuous process: The gas/solid system as a solution, Biotechnology and Bioengineering, vol.41, issue.5, pp.387-397, 1995.
DOI : 10.1002/bit.260450503

L. F. Garcia-alles and V. Gotor, Lipase-catalyzed transesterification in organic media: Solvent effects on equilibrium and individual rate constants, Biotechnology and Bioengineering, vol.263, issue.6, pp.684-694, 1998.
DOI : 10.1002/(SICI)1097-0290(19980920)59:6<684::AID-BIT5>3.0.CO;2-B

J. L. Schmitke, C. R. Wescott, and A. M. Klibanov, The Mechanistic Dissection of the Plunge in Enzymatic Activity upon Transition from Water to Anhydrous Solvents, Journal of the American Chemical Society, vol.118, issue.14, 1996.
DOI : 10.1021/ja9539958

P. P. Wangikar, T. P. Graycar, D. A. Estell, D. S. Clark, and J. S. Dordick, Protein and solvent engineering of subtilisin BPN' in nearly anhydrous organic media, Journal of the American Chemical Society, vol.115, issue.26, pp.12231-12237, 1993.
DOI : 10.1021/ja00079a001

-. Minn, J. H. Sowa, M. J. Charnick, S. B. Paulaitis, and M. E. , The hydration of proteins in nearly anhydrous organic solvent suspensions, Biopolymers, vol.202, issue.8, pp.1213-1224, 1993.
DOI : 10.1002/bip.360330808

-. Tol, J. B. Kraayveld, D. E. Jongejan, J. A. Duine, and J. A. , The catalytic performance of pig pancreas lipase in enantioselective transesterification in organic solvents, 1995.

M. Martinelle and K. Hult, Kinetics of acyl transfer reactions in organic media catalysed by Candida antarctica lipase B, Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, vol.1251, issue.2, pp.191-197, 1995.
DOI : 10.1016/0167-4838(95)00096-D

L. F. Garcia-alles and V. Gotor, Alcohol inhibition and specificity studies of lipase B fromCandida antarctica in organic solvents, Biotechnology and Bioengineering, vol.48, issue.2, pp.163-170, 1998.
DOI : 10.1002/(SICI)1097-0290(19980720)59:2<163::AID-BIT4>3.0.CO;2-F

-. , R. Bosley, J. Duri, and B. , Esterification of oleic acid and ethanol in plug flow (packed bed) reactor under supercritical conditions ? Investigation of kinetics, J. of Supercritical Fluids, vol.18, pp.121-130, 2000.

T. Anthonsen and T. A. Jones, Crystallographic and molecular modelling studies of lipase B from Candida antarctica reveal a stereospecificity pocket for secondary alcohols, Biochemistry, vol.34, pp.16838-16851, 1995.

G. Careri, M. Geraci, A. Giansanti, and J. A. Rupley, Protonic conductivity of hydrated lysozyme powders at megahertz frequencies., Proceedings of the National Academy of Sciences, vol.82, issue.16, pp.5342-5346, 1985.
DOI : 10.1073/pnas.82.16.5342