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Redox regulation of the hypoxia-inducible factor.

Abstract : Reactive oxygen species (ROS) have long been considered only as cyto- and genotoxic. However, there is now compelling evidence that ROS also act as second messengers in response to various stimuli, such as growth factors, hormones and cytokines. The hypoxia-inducible transcription factor (HIF) is a master regulator of oxygen-sensitive gene expression. More recently, HIF has also been shown to respond to non-hypoxic stimuli. Interestingly, recent reports indicate that ROS regulate HIF stability and transcriptional activity in well-oxygenated cells, as well as under hypoxic conditions. Consequently, ROS appear to be key players in regulating HIF-dependent pathways under both normal and pathological circumstances. This review summarizes the current understanding of the role of ROS in the regulation of the mammalian HIF system.
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Contributor : Cecilia Darcourt <>
Submitted on : Friday, September 12, 2008 - 10:40:19 AM
Last modification on : Monday, October 12, 2020 - 10:27:35 AM

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Jacques Pouysségur, Fatima Mechta-Grigoriou. Redox regulation of the hypoxia-inducible factor.. Biological Chemistry, De Gruyter, 2006, 387 (10-11), pp.1337-46. ⟨10.1515/BC.2006.167⟩. ⟨hal-00321043⟩



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