Effect of Sodium Doping in beta-Tricalcium Phosphate on Its Structure and Properties

Laetitia Obadia , Philippe Deniard (1) , Bruno Alonso (2) , Thierry Rouillon , Stéphane Jobic (1) , Jérôme Guicheux , Marion Julien , Dominique Massiot (2) , Bruno Bujoli (3) , Jean-Michel Bouler

1 IMN - Institut des Matériaux Jean Rouxel
2 CRMHT - Centre de recherches sur les matériaux à haute température
3 LSOHOOM - Laboratoire de Synthèse Organique (Hétérochimie organique, organoéléments et matériaux)

For the preparation of beta-TCP and biphasic calcium phosphates (BCPs, mixtures of hydroxyapatite and beta-TCP), the presence of sodium in the reaction medium results in the incorporation of sodium in the beta-TCP network, by substitution of some calcium sites. Accordingly, a decrease of the unit cell volume of -TCP was observed with increasing sodium substitution. The distribution of sodium in the beta-TCP structure, as a function of the amount incorporated, was probed using 31P and 23Na MAS NMR and 31P{23Na} REDOR experiments. It was shown that an estimation of the sodium content in beta-TCPs could be obtained from the modeling of their 31P MAS NMR spectra. Moreover, the incorporation of sodium in beta-TCPs results in improved mechanical properties, without affecting the biocompatibility of the ceramics.

Mots clés: Biomaterials; NMR; Biomaterials

Domaines: Matériaux

Laetitia Obadia, Philippe Deniard, Bruno Alonso, Thierry Rouillon, Stéphane Jobic, et al.. Effect of Sodium Doping in beta-Tricalcium Phosphate on Its Structure and Properties. Chemistry of Materials, 2006, 18, pp.1425-1433. ⟨10.1021/cm052135f⟩. ⟨hal-00019404⟩