Large-Scale, High-Resolution Data Acquisition System for Extracellular Recording of Electrophysiological Activity

Abstract : A platform for high spatial and temporal resolution electrophysiological recordings of in vitro electrogenic cell cultures handling 4096 electrodes at a full frame rate of 8 kHz is presented and validated by means of cardiomyocyte cultures. Based on an active pixel sensor device implementing an array of metallic electrodes, the system provides acquisitions at spatial resolutions of 42 µmon an active area of 2.67mm×2.67 mm, and in the zooming mode, temporal resolutions down to 8 µs on 64 randomly selected electrodes. The low-noise performances of the integrated ampli- fier (11 µVrms) combined with a hardware implementation inspired by image/video processing concepts enable high-resolution acquisitions with real-time preprocessing capabilities adapted to the handling of the large amount of acquired data.
Complete list of metadatas

https://hal.archives-ouvertes.fr/hal-00319351
Contributor : Sylvain Saighi <>
Submitted on : Monday, September 8, 2008 - 11:23:47 AM
Last modification on : Monday, February 11, 2019 - 4:42:01 PM

Identifiers

  • HAL Id : hal-00319351, version 1

Citation

K. Imfeld, S. Neukom, A. Maccione, Y. Bornat, S. Martinoia, et al.. Large-Scale, High-Resolution Data Acquisition System for Extracellular Recording of Electrophysiological Activity. IEEE Transactions on Biomedical Engineering, Institute of Electrical and Electronics Engineers, 2008, 55 (8), pp.2064-2073. ⟨hal-00319351⟩

Share

Metrics

Record views

158