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Involvement of NO-synthase and nicotinic receptors in learning in the honey bee.

Abstract : Restrained worker honey bees (Apis mellifera) are one of the main models for the comparative study of learning and memory processes. Bees easily learn to associate a sucrose reward to antennal tactile scanning of a small metal plate (associative learning). Their proboscis extension response can also be habituated through repeated sucrose stimulations (non-associative learning). We studied the role of nitric oxide synthase and nicotinic acetylcholine receptors in these two forms of learning. The nicotinic antagonist MLA or the nitric oxide synthase inhibitor l-NAME impaired the formation of tactile associative long-term memory that specifically occurs during multiple-trial training; however these drugs had no effect on single-trial training. None of the drugs affected retrieval processes. These pharmacological results are consistent with data previously obtained with olfactory conditioning and indicate that MLA-sensitive nicotinic receptors and NO-synthase are specifically involved in long-term memory. MLA and l-NAME both reduced the number of trials required for habituation to occur. This result suggests that a reduction of cholinergic nicotinic neurotransmission promotes PER habituation in the honey bee.
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https://hal.archives-ouvertes.fr/hal-00318760
Contributor : Martin Giurfa Connect in order to contact the contributor
Submitted on : Thursday, September 4, 2008 - 10:31:54 PM
Last modification on : Wednesday, October 14, 2020 - 4:11:05 AM

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M. Dacher, Mélanie Gauthier. Involvement of NO-synthase and nicotinic receptors in learning in the honey bee.. Physiology and Behavior, Elsevier, 2008, 95 (1-2), pp.200-7. ⟨10.1016/j.physbeh.2008.05.019⟩. ⟨hal-00318760⟩

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