Synthesis of small molecule CDC25 phosphatases inhibitors.

Marie-Odile Contour-Galcéra (1) , Olivier Lavergne (1) , Marie-Christine Brezak (1) , Bernard Ducommun (2) , Grégoire Prévost (1)

1 IPSEN - Institut Henri Beaufour
2 LBCMCP - Laboratoire de Biologie Cellulaire et Moléculaire du Contrôle de la Prolifération

A targeted library of small molecules has been prepared to optimize the biological activity of BN82002, our initial lead compound, recently described as an original inhibitor of CDC25 phosphatases. Some of these compounds inhibit CDC25 in the micromolar range and therefore reinforce the interest of CDC25 as an anticancer target.

Domaines: Biologie cellulaire

Marie-Odile Contour-Galcéra, Olivier Lavergne, Marie-Christine Brezak, Bernard Ducommun, Grégoire Prévost. Synthesis of small molecule CDC25 phosphatases inhibitors.. Bioorganic and Medicinal Chemistry Letters, 2004, 14 (23), pp.5809-12. ⟨10.1016/j.bmcl.2004.09.041⟩. ⟨hal-00317432⟩